Intestinal phages interact with bacteria and are involved in human diseases
H Shuwen, D Kefeng - Gut Microbes, 2022 - Taylor & Francis
Phages are the most abundant and diverse biological entities on Earth and exert specific
effects on bacterial hosts. The coexistence of phages and bacteria in the intestinal tract is …
effects on bacterial hosts. The coexistence of phages and bacteria in the intestinal tract is …
Mycobacterium tuberculosis strain with deletions in menT3 and menT4 is attenuated and confers protection in mice and guinea pigs
The genome of Mycobacterium tuberculosis encodes for a large repertoire of toxin-antitoxin
systems. In the present study, MenT3 and MenT4 toxins belonging to MenAT subfamily of TA …
systems. In the present study, MenT3 and MenT4 toxins belonging to MenAT subfamily of TA …
Cryo‐EM structure of antibacterial efflux transporter QacA from Staphylococcus aureus reveals a novel extracellular loop with allosteric role
Efflux of antibacterial compounds is a major mechanism for developing antimicrobial
resistance. In the Gram‐positive pathogen Staphylococcus aureus, QacA, a 14 …
resistance. In the Gram‐positive pathogen Staphylococcus aureus, QacA, a 14 …
[HTML][HTML] A comparative analysis of mycobacterial ribonucleases: Toward a therapeutic novel drug target
LK Jaiswal, RK Singh, T Nayak, A Kakkar… - Infection, Genetics and …, 2024 - Elsevier
Bacterial responses to continuously changing environments are addressed through
modulation of gene expression at the level of transcription initiation, RNA processing and/or …
modulation of gene expression at the level of transcription initiation, RNA processing and/or …
Structural and mutational analysis of MazE6-operator DNA complex provide insights into autoregulation of toxin-antitoxin systems
K Kumari, SP Sarma - Communications Biology, 2022 - nature.com
Of the 10 paralogs of MazEF Toxin-Antitoxin system in Mycobacterium tuberculosis, MazEF6
plays an important role in multidrug tolerance, virulence, stress adaptation and Non …
plays an important role in multidrug tolerance, virulence, stress adaptation and Non …
Deciphering the role of VapBC13 and VapBC26 toxin antitoxin systems in the pathophysiology of Mycobacterium tuberculosis
The expansion of VapBC TA systems in M. tuberculosis has been linked with its fitness and
survival upon exposure to stress conditions. Here, we have functionally characterized …
survival upon exposure to stress conditions. Here, we have functionally characterized …
MazEF toxin–antitoxin systems: their role in Mycobacterium tuberculosis stress response and drug resistance
The remarkable ability of Mtb to persist within host renders its treatment and eradication
quite challenging [1]. Toxin-Antitoxin (TA) systems are genetic modules found in both …
quite challenging [1]. Toxin-Antitoxin (TA) systems are genetic modules found in both …
The whole genome sequence of Polish vaccine strain Mycobacterium bovis BCG Moreau
K Krysztopa-Grzybowska, J Lach, M Polak… - Microbiology …, 2024 - Am Soc Microbiol
Currently, tuberculosis immunoprophylaxis is based solely on Bacillus Calmette-Guérin
(BCG) vaccination, and some of the new potential tuberculosis vaccines are based on the …
(BCG) vaccination, and some of the new potential tuberculosis vaccines are based on the …
Insights into the solution structure and transcriptional regulation of the MazE9 antitoxin in Mycobacterium tuberculosis
TB Roy, SP Sarma - Proteins: Structure, Function, and …, 2023 - Wiley Online Library
The present study endeavors to decode the details of the transcriptional autoregulation
effected by the MazE9 antitoxin of the Mycobacterium tuberculosis MazEF9 toxin–antitoxin …
effected by the MazE9 antitoxin of the Mycobacterium tuberculosis MazEF9 toxin–antitoxin …
Combining cysteine scanning with chemical labeling to map protein-protein interactions and infer bound structure in an intrinsically disordered region
The Mycobacterium tuberculosis genome harbours nine toxin-antitoxin (TA) systems of the
mazEF family. These consist of two proteins, a toxin and an antitoxin, encoded in an operon …
mazEF family. These consist of two proteins, a toxin and an antitoxin, encoded in an operon …