The therapeutic age of the neonatal Fc receptor

M Pyzik, LK Kozicky, AK Gandhi… - Nature Reviews …, 2023 - nature.com
IgGs are essential soluble components of the adaptive immune response that evolved to
protect the body from infection. Compared with other immunoglobulins, the role of IgGs is …

Cross-reactive immunity among flaviviruses

APS Rathore, AL St. John - Frontiers in immunology, 2020 - frontiersin.org
Flaviviruses consist of significant human pathogens responsible for hundreds of millions of
infections each year. Their antigenic relationships generate immune responses that are …

Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE

R Msallam, J Balla, APS Rathore, H Kared, B Malleret… - Science, 2020 - science.org
Mast cells (MCs) are central effector cells in allergic reactions that are often mediated by
immunoglobulin E (IgE). Allergies commonly start at an early age, and both MCs and IgE are …

Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity

CQE Lee, B Kerouanton, S Chothani, S Zhang… - Nature …, 2021 - nature.com
Mito-SEPs are small open reading frame-encoded peptides that localize to the mitochondria
to regulate metabolism. Motivated by an intriguing negative association between mito-SEPs …

Serological cross-reactivity among common flaviviruses

KR Chan, AA Ismail, G Thergarajan, CS Raju… - Frontiers in Cellular …, 2022 - frontiersin.org
The Flavivirus genus is made up of viruses that are either mosquito-borne or tick-borne and
other viruses transmitted by unknown vectors. Flaviviruses present a significant threat to …

Innate immune mechanisms to protect against infection at the human decidual-placental interface

R Hoo, A Nakimuli, R Vento-Tormo - Frontiers in immunology, 2020 - frontiersin.org
During pregnancy, the placenta forms the anatomical barrier between the mother and
developing fetus. Infectious agents can potentially breach the placental barrier resulting in …

[HTML][HTML] A Zika virus mutation enhances transmission potential and confers escape from protective dengue virus immunity

JA Regla-Nava, YT Wang, CR Fontes-Garfias, Y Liu… - Cell reports, 2022 - cell.com
Zika virus (ZIKV) and dengue virus (DENV) are arthropod-borne pathogenic flaviviruses that
co-circulate in many countries. To understand some of the pressures that influence ZIKV …

Exacerbated Zika virus–induced neuropathology and microcephaly in fetuses of dengue-immune nonhuman primates

WAA Saron, K Shanmugam, CC Tung… - Science Translational …, 2023 - science.org
Zika virus (ZIKV) is a mosquito-borne flavivirus that can vertically transmit from mother to
fetus, potentially causing congenital defects, including microcephaly. It is not fully …

Perspectives on the technological aspects and biomedical applications of virus‐like particles/nanoparticles in reproductive biology: insights on the medicinal and …

V Chandrasekar, AV Singh… - Advanced …, 2022 - Wiley Online Library
Increasing data on the infection indicate that maternal infections are severe. Under the
realms of vaccine development, virus‐like particles (VLP)/nanoparticles (NPs) hold the …

Impact of prior dengue virus infection on Zika virus infection during pregnancy in marmosets

IJ Kim, MP Tighe, MJ Clark, GD Gromowski… - Science Translational …, 2023 - science.org
Zika virus (ZIKV) infection during pregnancy causes severe developmental defects in
newborns, termed congenital Zika syndrome (CZS). Factors contributing to a surge in ZIKV …