Aldehyde dehydrogenase (ALDH) is a superfamily of enzymes that detoxify a variety of
endogenous and exogenous aldehydes and are required for the biosynthesis of retinoic …

The oxetane ring is an emergent, underexplored motif in drug discovery that shows attractive
properties such as low molecular weight, high polarity, and marked three-dimensionality …

Aldehyde dehydrogenases (ALDHs) are promising cancer drug targets, as certain isoforms
are required for the survival of stem-like tumor cells. We have discovered selective inhibitors …

Ovarian cancer is typified by the development of chemotherapy resistance. Chemotherapy
resistance is associated with high aldehyde dehydrogenase (ALDH) enzymatic activity …

Solid tumors can be divided into benign solid tumors and solid malignant tumors in the
academic community, among which malignant solid tumors are called cancers. Cancer is …

Aldehyde dehydrogenase (ALDH) is a proposed biomarker and possible target to eradicate
cancer stem cells. ALDH inhibition as a treatment approach is supported by anti-cancer …

Novel pyrazolo[3,4-d]pyrimidines as potential anticancer agents: Synthesis, VEGFR-2 inhibition,
and mechanisms of action - ScienceDirect Skip to main contentSkip to article Elsevier logo …

Triple-negative breast cancer (TNBCs) account for 15–20% of all breast cancers and
represent the most aggressive subtype of this malignancy. Early tumor relapse and …

The compact and versatile oxetane motifs have gained significant attention in drug discovery
and medicinal chemistry programs. This review presents an overview of the diverse …

The majority of women diagnosed with epithelial ovarian cancer eventually develop
recurrence, which rapidly evolves into chemoresistant disease. Persistence of ovarian …