Abstract Currently, 5.4 million Americans suffer from AD, and these numbers are expected to
increase up to 16 million by 2050. Despite tremendous research efforts, we still do not have …

The change from viewing noncoding RNA as “junk” in the genome to seeing it as a critical
epigenetic regulator in almost every human condition or disease has forced a paradigm shift …

Transcriptional dysregulation in Huntington's disease (HD) is an early event that shapes the
brain transcriptome by both the depletion and ectopic activation of gene products that …

Abstract Background Huntington's Disease (HD) is a progressive neurodegenerative
disorder with a single causal mutation in the Huntingtin (HTT) gene. MicroRNAs (miRNAs) …

One of the roadblocks to developing effective therapeutics for Huntington disease (HD) is
the lack of animal models that develop progressive clinical traits comparable to those seen …

Huntington's disease (HD) is one of neurodegenerative diseases, and is defined as a
monogenetic disease due to the mutation of Huntingtin gene. This disease affects several …

Genetically modified rodent models of Huntington's disease (HD) have been especially
valuable to our understanding of HD pathology and the mechanisms by which the mutant …

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by the
expansion of polyglutamine (polyQ) tract that leads to motor, cognitive and psychiatric …

Transgenic Huntington's disease monkey (HD monkey) model provides great opportunity for
studying disease progression that could lead to new insight for developing biomarker, early …

Transgenic nonhuman primate models are an increasingly popular model for neurologic
and neurodegenerative disease because their brain functions and neural anatomies closely …