Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …

For decades, it was commonly accepted that the brain is secluded from peripheral immune
activity and is self-sufficient for its maintenance and repair. This simplistic perception was …

Neuropathic pain is often caused by injury and diseases that affect the somatosensory
system. Although pain development has been well studied, pain recovery mechanisms …

Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

The CNS is ensheathed by the meninges and cerebrospinal fluid, and recent findings
suggest that these CNS-associated border tissues have complex immunological functions …

The segregation and limited regenerative capacity of the CNS necessitate a specialized and
tightly regulated resident immune system that continuously guards the CNS against invading …

Macrophages are present in all vertebrate tissues, from mid-gestation throughout life,
constituting a widely dispersed organ system. They promote homeostasis by responding to …

Hypertension (HTN), a disease afflicting over one billion individuals worldwide, is a leading
cause of cognitive impairment, the mechanisms of which remain poorly understood. In the …

Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults.
Currently, the standard treatment of glioblastoma includes surgery, radiotherapy, and …

The central nervous system (CNS) and its meningeal coverings accommodate a diverse
myeloid compartment that includes parenchymal microglia and perivascular macrophages …