Esophageal adenocarcinoma (EAC) is rapidly increasing in incidence and is associated
with a poor prognosis. Barrett's esophagus (BE) is a known precursor of esophageal …

Background Exploration of the genes with abnormal expression during the development of
breast cancer is essential to provide a deeper understanding of the mechanisms involved …

Wound repair is a highly regulated process that requires the interaction of various cell types.
It has been shown that cancers use the mechanisms of wound healing to promote their own …

Effective targeting of cancer-associated fibroblasts (CAFs) is hindered by the lack of specific
biomarkers and a poor understanding of the mechanisms by which different populations of …

Inhibin subunit beta A (INHBA) participates in the synthesis of inhibin A, activin A and activin
AB. Here we investigated the effect and molecular mechanism of INHBA on proliferation …

Abstract Activin A (ActA)/follistatin (FST) signaling has been shown to be deregulated in
different tumor types including lung adenocarcinoma (LADC). Here, we report that serum …

Pancreatic ductal adenocarcinoma (PDAC) has extensive stromal involvement and remains
one of the cancers with the highest mortality rates. Activin A has been implicated in colon …

Esophageal adenocarcinoma (EAC) has one of the fastest rising incidence rates in the US
and many other Western countries. One of the unique risk factors for EAC is …

Inspired by the vascular-disrupting agent combretastatin A-4 and recently published
anticancer active N-heterocyclic carbene (NHC) complexes of Au (I), a series of new …

The Activin-A precursor dimer can be cleaved by furin, but how this proteolytic maturation is
regulated in vivo and how it facilitates access to signaling receptors is unclear. Here …