Proteomic discovery of non-invasive biomarkers of localized prostate cancer using mass spectrometry

A Khoo, LY Liu, JO Nyalwidhe, OJ Semmes… - Nature Reviews …, 2021 - nature.com
Prostate cancer is the second most frequently diagnosed non-skin cancer in men worldwide.
Patient outcomes are remarkably heterogeneous and the best existing clinical prognostic …

[HTML][HTML] MicroRNAs as clinical tools for diagnosis, prognosis, and therapy in prostate cancer

F Ghamlouche, A Yehya, Y Zeid, H Fakhereddine… - Translational …, 2023 - Elsevier
Prostate cancer (PCa) is one of the most commonly diagnosed cancers among men
worldwide. Despite the presence of accumulated clinical strategies for PCa management …

DNA Tile and Invading Stacking Primer-Assisted CRISPR–Cas12a Multiple Amplification System for Entropy-Driven Electrochemical Detection of MicroRNA with …

H Wang, YL Li, YJ Fan, JX Dong, X Ren, H Ma… - Analytical …, 2023 - ACS Publications
Conventional electrochemical detection of microRNA (miRNA) encounters issues of poor
sensitivity and fixed dynamic range. Here, we report a DNA tile and invading stacking primer …

Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in‐depth proteomic analysis

VL Correll, JJ Otto, CM Risi, BP Main… - Journal of …, 2022 - Wiley Online Library
The isolation and subsequent molecular analysis of extracellular vesicles (EVs) derived from
patient samples is a widely used strategy to understand vesicle biology and to facilitate …

Prostate cancer reshapes the secreted and extracellular vesicle urinary proteomes

A Khoo, M Govindarajan, Z Qiu, LY Liu… - Nature …, 2024 - nature.com
Urine is a complex biofluid that reflects both overall physiologic state and the state of the
genitourinary tissues through which it passes. It contains both secreted proteins and proteins …

Early molecular markers for retrospective biodosimetry and prediction of acute health effects

M Abend, WF Blakely, P Ostheim… - Journal of …, 2022 - iopscience.iop.org
Radiation-induced biological changes occurring within hours and days after irradiation can
be potentially used for either exposure reconstruction (retrospective dosimetry) or the …

Clinical proteomics for prostate cancer: understanding prostate cancer pathology and protein biomarkers for improved disease management

C Tonry, S Finn, J Armstrong, SR Pennington - Clinical Proteomics, 2020 - Springer
Following the introduction of routine Prostate Specific Antigen (PSA) screening in the early
1990′ s, Prostate Cancer (PCa) is often detected at an early stage. There are also a …

MiRNA biomarkers in cancers of the male reproductive system: are we approaching clinical application?

V Constâncio, NT Tavares, R Henrique… - …, 2023 - Wiley Online Library
Background Specific cancer types face specific clinical management challenges. Owing to
their stability, robustness and fast, easy and cost‐effective detection, microRNAs (miRNAs) …

Urinary microRNAs and their significance in prostate cancer diagnosis: a 5-year update

J Juracek, M Madrzyk, M Stanik, O Slaby - Cancers, 2022 - mdpi.com
Simple Summary Current diagnostics of prostate cancer often show unsatisfactory results,
leading to delayed detection or overtreatment. Urinary microRNAs are a class of promising …

Ultrasensitive fluorescence detection and accurate colocalization visualization of dual-miRNAs in cancer cells based on the conjugated chain reaction of …

F Liu, Z Yang, J Zhou, Y Chai, R Yuan… - Analytical …, 2022 - ACS Publications
Herein, a multifunctional pentagon DNA nanostructure (MPDN) was assembled by the
hybridization of a circular DNA scaffold containing five different fragments with five diverse …