Cancer is a black spot on the face of humanity in this era of science and technology.
Presently, several classes of anticancer drugs are available in the market, but issues such …

Imidazole ring is an important five‐membered aromatic heterocycle widely present in natural
products and synthetic molecules. The unique structural feature of imidazole ring with …

Serine/threonine-protein kinase B-Raf (BRAF; RAF= rapidly accelerated fibrosarcoma) plays
an important role in the mitogen-activated protein kinase (MAPK) signaling cascade …

The RAS/mitogen-activated protein kinase (MAPK) signaling cascade is commonly
dysregulated in human malignancies by processes driven by RAS or RAF oncogenes …

Abstract BRAF V600E mutation has been detected in various malignant tumours.
Developing of potent BRAF V600E inhibitors is considered a leading step in the way to cure …

Frequent oncogenic mutations have been identified in MAPK (mitogen-activated protein
kinase) signaling pathway components. As a result, MAPK pathway is associated with …

Synthesis of a new series of diarylureas and diarylamides possessing 1, 3, 4-triarylpyrazole
scaffold is described. Their in vitro antiproliferative activities against 9 human melanoma cell …

Cancer, one of the key health problems globally, is a group of related diseases that share a
number of characteristics primarily the uncontrolled growth and invasive to surrounding …

Melanoma is an aggressive form of skin cancer and it is generally associated with poor
prognosis in patients with late-stage disease. Due to the increasing occurrence of …

Synthesis of a new series of diarylamides possessing 6, 7-dimethoxy (dihydroxy) quinoline
scaffold is described. Their in vitro antiproliferative activities against NCI-58 human cancer …