The lifespan human connectome project in aging: an overview

SY Bookheimer, DH Salat, M Terpstra, BM Ances… - Neuroimage, 2019 - Elsevier
Abstract The original Human Connectome Project yielded a rich data set on structural and
functional connectivity in a large sample of healthy young adults using improved methods of …

The medial temporal lobe

LR Squire, CEL Stark, RE Clark - Annu. Rev. Neurosci., 2004 - annualreviews.org
▪ Abstract The medial temporal lobe includes a system of anatomically related structures that
are essential for declarative memory (conscious memory for facts and events). The system …

Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease

UA Khan, L Liu, FA Provenzano, DE Berman… - Nature …, 2014 - nature.com
The entorhinal cortex has been implicated in the early stages of Alzheimer's disease, which
is characterized by changes in the tau protein and in the cleaved fragments of the amyloid …

Quantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal subregions in in vivo MRI: towards a harmonized segmentation …

PA Yushkevich, RSC Amaral, JC Augustinack… - Neuroimage, 2015 - Elsevier
Objective An increasing number of human in vivo magnetic resonance imaging (MRI)
studies have focused on examining the structure and function of the subfields of the …

Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance

AR Hariri, TE Goldberg, VS Mattay… - Journal of …, 2003 - Soc Neuroscience
BDNF plays a critical role in activity-dependent neuroplasticity underlying learning and
memory in the hippocampus. A frequent single nucleotide polymorphism in the targeting …

Prospective representation of navigational goals in the human hippocampus

TI Brown, VA Carr, KF LaRocque, SE Favila… - Science, 2016 - science.org
Mental representation of the future is a fundamental component of goal-directed behavior.
Computational and animal models highlight prospective spatial coding in the hippocampus …

CA1 and CA3 differentially support spontaneous retrieval of episodic contexts within human hippocampal subfields

HR Dimsdale-Zucker, M Ritchey, AD Ekstrom… - Nature …, 2018 - nature.com
The hippocampus plays a critical role in spatial and episodic memory. Mechanistic models
predict that hippocampal subfields have computational specializations that differentially …

A unified framework for the functional organization of the medial temporal lobes and the phenomenology of episodic memory

C Ranganath - Hippocampus, 2010 - Wiley Online Library
There is currently an intense debate about the nature of recognition memory and about the
roles of medial temporal lobe subregions in recognition memory processes. At a larger level …

Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease

SG Mueller, N Schuff, K Yaffe, C Madison… - Human brain …, 2010 - Wiley Online Library
Background: Histopathological studies and animal models suggest that hippocampal
subfields may be differently affected by aging, Alzheimer's disease (AD), and other diseases …

Automated segmentation of hippocampal subfields from ultra‐high resolution in vivo MRI

K Van Leemput, A Bakkour, T Benner, G Wiggins… - …, 2009 - Wiley Online Library
Recent developments in MRI data acquisition technology are starting to yield images that
show anatomical features of the hippocampal formation at an unprecedented level of detail …