Mast cells are immune cells of the haematopoietic lineage that are now thought to have
multifaceted functions during homeostasis and in various disease states. Furthermore, while …

Mast cells have existed long before the development of adaptive immunity, although they
have been given different names. Thus, in the marine urochordate Styela plicata, they have …

The origin and functions of mast cells (MCs) have been debated since their description by
Paul Ehrlich in 1879. MCs have long been considered'reactive bystanders' and'amplifiers' in …

Mast cells are found resident in tissues throughout the body, particularly in association with
structures such as blood vessels and nerves, and in proximity to surfaces that interface the …

The discovery in 1987/1988 and 1990 of the cell surface receptor KIT and its ligand, stem
cell factor (SCF), was a critical achievement in efforts to understand the development and …

Stem cell factor (SCF; also known as kit ligand, mast cell ultimate destinations during
development. Hematopoietic cells growth factor, or steel factor) is a hematopoietic cytokine …

Mast cells have mainly been studied in the setting of allergic disease, but the importance of
mast cells for host defence against several pathogens has now been well established. The …

STI 571 (formerly known as CGP 57148B) is a known inhibitor of the c-abl, bcr-abl, and
platelet-derived growth-factor receptor (PDGFR) tyrosine kinases. This compound is being …

Imatinib is a potent and selective inhibitor of the protein tyrosine kinase Bcr-Abl, platelet-
derived growth factor receptors (PDGFRα and PDGFRβ) and KIT. Imatinib is approved for …

Most physicians and immunologists, if they think of the mast cell at all, regard it as something
of a pariah. Other cells of hematopoietic origin, such as neutrophils, macrophages, and …