Human immunodeficiency virus type 2

JD Reeves, RW Doms - Journal of general virology, 2002 - microbiologyresearch.org
The AIDS pandemic continues to spread unchecked in many parts of the world, with greater
than 34 million individuals currently infected with human immunodeficiency virus (HIV) …

90-90-90 for HIV-2? Ending the HIV-2 epidemic by enhancing care and clinical management of patients infected with HIV-2

GS Gottlieb, DN Raugi, RA Smith - The lancet HIV, 2018 - thelancet.com
Distinct from HIV-1 and often neglected in the global campaign to end the AIDS epidemic,
HIV-2 presents unique and underappreciated challenges in diagnosis, clinical care …

Reduced rate of disease development after HIV-2 infection as compared to HIV-1

R Marlink, P Kanki, I Thior, K Travers, G Eisen, T Siby… - Science, 1994 - science.org
Human immunodeficiency virus type-2 (HIV-2) is a close relative of the prototype acquired
immunodeficiency syndrome (AIDS) virus, HIV-1. HIV-2 is biologically similar to HIV-1, but …

CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load

AE Sousa, J Carneiro… - The Journal of …, 2002 - journals.aai.org
The causal relationships among CD4 cell depletion, HIV replication, and immune activation
are not well understood. HIV-2 infection,“nature's experiment” with inherently attenuated HIV …

HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women

S Rowland-Jones, J Sutton, K Ariyoshi, T Dong… - Nature medicine, 1995 - nature.com
A crucial requirement in the rational design of a prophylactic vaccine against the hu-uman
immunodeficiency virus (HIV) is to establish whether or not protective immunity can occur …

Comparison of HIV‐1 and HIV‐2 infectivity from a prospective cohort study in Senegal

PB Gilbert, IW McKeague, G Eisen… - Statistics in …, 2003 - Wiley Online Library
From a prospective cohort study of 1948 initially human immunodeficiency virus (HIV)
uninfected female commercial sex workers followed between 1985 and 1999 in Dakar …

Genetic diversity of human immunodeficiency virus type 2: evidence for distinct sequence subtypes with differences in virus biology

F Gao, L Yue, DL Robertson, SC Hill, H Hui… - Journal of …, 1994 - Am Soc Microbiol
The virulence properties of human immunodeficiency virus type 2 (HIV-2) are known to vary
significantly and to range from relative attenuation in certain individuals to high-level …

The associations between cervicovaginal HIV shedding, sexually transmitted diseases and immunosuppression in female sex workers in Abidjan, Cote d'Ivoire

PD Ghys, K Fransen, MO Diallo, V Ettiègne-Traoré… - Aids, 1997 - journals.lww.com
Objective: To measure the frequency and associated factors of cervicovaginal HIV shedding
and to determine the impact of sexually transmitted disease (STD) treatment on HIV …

Lower human immunodeficiency virus (HIV) type 2 viral load reflects the difference in pathogenicity of HIV-1 and HIV-2

SJ Popper, AD Sarr, KU Travers… - The Journal of …, 1999 - academic.oup.com
Human immunodeficiency virus type 2 (HIV-2) is less pathogenic than HIV type 1 (HIV-1),
but the mechanisms underlying this difference have not been defined. We developed an …

Epidemiology and transmission of HIV-2: why there is no HIV-2 pandemic

KM De Cock, G Adjorlolo, E Ekpini, T Sibailly… - Jama, 1993 - jamanetwork.com
Although human immunodeficiency virus type 1 (HIV-1) and HIV-2 share modes of
transmission, their epidemiologic characteristics differ and international spread of HIV-2 has …