The evolutionary origins of the three major families of chemoreceptors in arthropods—the
odorant receptor (OR), gustatory receptor (GR), and ionotropic receptor (IR) families …

Genetic approaches in the fruit fly, Drosophila melanogaster, have led to a major triumph in
the field of sensory biology—the discovery of multiple large families of sensory receptors …

Insects rely on a family of seven transmembrane proteins called gustatory receptors (GRs) to
encode different taste modalities, such as sweet and bitter. We report structures of …

INTRODUCTION Global brain states such as sleep and wakefulness involve
reconfigurations of neural circuit activity across the entire nervous system. Yet it is not …

Animals display selective escape behaviors when faced with environmental threats.
Selection of the appropriate response by the underlying neuronal network is key to …

Personalized cancer therapy targeting somatic mutations in patient tumors is increasingly
being incorporated into practice. Other therapeutic vulnerabilities resulting from changes in …

Caenorhabditis elegans lives in a complex habitat in which they routinely experience large
fluctuations in temperature, and encounter physical obstacles that vary in size and …

The wiring architecture of neuronal networks is assumed to be a strong determinant of their
dynamical computations. An ongoing effort in neuroscience is therefore to generate …

Unlike olfaction, taste, touch, vision, and proprioception, which are widespread across
animal phyla, hearing is found only in vertebrates and some arthropods. The vast majority of …

Rearrangments in Histone-lysine-N-methyltransferase 2A (KMT2Ar) are associated with
pediatric, adult and therapy-induced acute leukemias. Infants with KMT2Ar acute …