Vanin 1 gene role in modulation of iNOS/MCP-1/TGF-β1 signaling pathway in obese diabetic patients

YO Mosaad, MA Hussein, H Ateyya… - Journal of …, 2022 - Taylor & Francis
Introduction Cysteamine, a powerful endogenous antioxidant, is produced mostly by the
vanin-1 with pantetheinase activity. With regard to glycemic, inflammatory, and redox factors …

Optimization of Naringenin-loaded nanoparticles for targeting of Vanin-1, iNOS, and MCP-1 signaling pathway in HFD-induced obesity

A Salah, NM El-Laban, SM Alam, MS Islam… - International Journal of …, 2024 - Elsevier
Naringenin, a natural dihydrochalcone flavonoid, exhibits diverse pharmacological
properties. This study investigates the hypolipidemic effects of Nar-NPs on obese mice. The …

A novel quinazoline-4-one derivatives as a promising cytokine inhibitors: Synthesis, molecular docking, and structure-activity relationship

RM Borik, MA Hussein - Current Pharmaceutical Biotechnology, 2022 - ingentaconnect.com
Background: Quinazolines are a common class of nitrogen-containing heterocyclic scaffolds,
which exhibit a broad spectrum of pharmacological activities. Objectives: In the present …

[HTML][HTML] Malva parviflora seed oil; Isolation, gas chromatographic profiling and its cardioprotective activity against myocardial infraction in animal model

MA Hussein, MS Islam, AA Ali, MS Mansour… - Journal of King Saud …, 2024 - Elsevier
Myocardial infarction (MI), one of the most perilous types of cardiac illness, carries a
significant burden of mortality and morbidity. This study aims to shed light on the impact of …

Synthesis of cinnamyl and caffeoyl derivatives of Cucurbitacin-Eglycoside Isolated from Citrullus colocynthis fruits and their structures antioxidant and anti …

MA Hussein, HAE El-Gizawy… - Current …, 2017 - ingentaconnect.com
Background: Citrullus colocynthis (L.) Schrad is an important medicinal plant belonging to
the family Cucurbitaceae. Cucurbitacin E glucoside (1) was isolated from Citrullus …

Optimization of Phloretin-loaded Nanospanlastics for Targeting of FAS/SREBP1c/AMPK/ OB-Rb Signaling Pathway in HFD-induced Obesity

M Alamir, MA Hussein, HM Aboud… - Current …, 2025 - benthamdirect.com
Objectives Obese patients are at increased risk for CVD, which is the main cause of
premature death and has been a major cause of disability and ill health in recent years …

Synthesis, anti-inflammatory, and structure antioxidant activity relationship of novel 4-quinazoline

MA Hussein - Medicinal Chemistry Research, 2013 - Springer
The practice of medicinal chemistry is devoted to the discovery and development of new
agents for treating disease. A new derivative of methyl 2-((E)-3-(3, 4-dihydroxyphenyl) …

Anti-inflammatory effect of natural heterocycle glucoside vicine obtained from Vicia faba L. its aglucone (divicine) their effect on some oxidative stress biomarkers in …

MA Hussein - Free Radicals and Antioxidants, 2012 - Elsevier
Background: Inflammation is typically characterized by increased permeability of endothelial
tissue resulting in oedema. Much of pyrimidine derivatives have been highly useful for …

Green synthesis of RES-CMCS: A promising modulator of the GLUT-4/Leptin Signaling Pathway in HFD-induced insulin resistance

A Salah, A Hussein, SA Hassan… - Biomedical …, 2022 - bmrat.biomedpress.org
Introduction: Resveratrol (RES) is a multi-biofunctional compound found in grapes and
mulberries. The present investigation was aimed at the green synthesis of resveratrol …

CAPE improves vanin-1/AKT/miRNA-203 signaling pathways in DSS-induced ulcerative colitis

AM Metwaly, HM Elmoghazy, MA Hussein… - … Research and Therapy, 2022 - bmrat.com
Introduction: Ulcerative colitis (UC) and other inflammatory bowel diseases (IBDs) are
common chronic, inflammatory gastrointestinal diseases. Due to their antioxidant, anti …