Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …

Platelets are anuclear blood cells required for haemostasis and are implicated in other
processes including inflammation and metastasis. Platelets are produced by …

Recent advances in immunology enabled the characterization of several signal transmitting
pathways responsible for proper cytokine and chemokine signaling. Among them, Janus …

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet
counts due to enhanced platelet clearance and compromised production. Traditionally, ITP …

The role of ABCC4, an ATP-binding cassette transporter, in the process of platelet formation,
megakaryopoiesis, is unknown. Here, we show that ABCC4 is highly expressed in …

Interleukins, a diverse family of cytokines produced by various cells, play crucial roles in
immune responses, immunoregulation, and a wide range of physiological and pathological …

Background Retinal ischemia–reperfusion (I/R) serves as a significant contributor to ocular
diseases, triggering a cascade of pathological processes. The interplay between …

Several protocols exist for generating megakaryocytes (MKs) and platelets from human
induced pluripotent stem cells (hiPSCs) with limited efficiency. We observed previously that …

Megakaryocytes (MKs), which are traditionally known for their role in platelet production, are
now emerging as unique immune cells with diverse capabilities. They express immune …

JAK3-activating mutations are commonly seen in chronic or acute hematologic malignancies
affecting the myeloid, megakaryocytic, lymphoid, and natural killer (NK) cell compartment …