Microgravity exposure causes several physiological and psychosocial alterations that
challenge astronauts' health during space flight. Notably, many of these changes are mostly …

Due to the impact that frailty and cardiac aging have on society and health systems, the
mechanisms surrounding these conditions must be known. If the frailty and cardiovascular …

In patients with liver cirrhosis (LC), sarcopenia is correlated with frequent complications and
increased mortality. Myostatin, a myokine, is a potential biomarker of skeletal mass and/or …

Aims Physical frailty is highly prevalent and predictive of worse outcomes in heart failure
(HF). Candidate biomarker analysis may help in understanding the mechanisms underlying …

Resistance training and protein supplementation are expected to exert the greatest effect in
counteracting muscle-wasting conditions. Myokines might play a key role, but this remains to …

Background Myostatin is a negative regulator of skeletal muscle mass. On the other hand,
growth differentiation factor (GDF)-15 is associated with lower muscle strength and muscle …

The prevalence of sarcopenia in inflammatory bowel disease patients has received
increasing attention. The aim of this study is to assess the usefulness of determining levels …

The burden of cardiovascular disease and the percentage of frail patients in the aging
population will increase. This study aims to assess the circulating levels of several cytokines …

Sarcopenia is linked to the decline in muscle mass, strength and function during aging. It
affects the quality and life expectancy and can lead to dependence. The biological process …

Frailty is characterized by loss of physical function and is preferably diagnosed at an early
stage (eg, during pre-frailty). Unfortunately, sensitive tools that can aid early detection are …