Background: NPS belonging to the benzodiazepine (BZD) class, eg,'legal/designer
BZDs'/'research chemicals', have recently emerged in the drug (mainly online/virtual) market …

The bromo and extra C-terminal domain (BET) family of bromodomains are involved in
binding epigenetic marks on histone proteins, more specifically acetylated lysine residues …

Respiratory syncytial virus (RSV) infections remain a significant public health problem
throughout the world, although recently developed and clinically approved anti-RSV …

Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract
infections worldwide, yet no effective vaccine or antiviral treatment is available. Here we …

A palladium-catalyzed cascade cross-coupling of acetanilide and toluene for the synthesis
of ortho-acylacetanilide is described. Toluene derivatives can act as effective acyl …

Tri-and tetracyclic nitrogen-bridgehead compounds were designed and synthesized to yield
micromolar cholinesterase (ChE) inhibitors. Structure–activity relationships identified potent …

EDP-938 is a novel non-fusion replication inhibitor of respiratory syncytial virus (RSV). It is
highly active against all RSV-A and B laboratory strains and clinical isolates tested in vitro in …

Presented herein is an unprecedented transition‐metal‐free propargylic substitution
reaction with either azolium enolates or acyl anions, which are generated from aldehydes …

Respiratory syncytial virus (RSV) is the cause of one-fifth of all lower respiratory tract
infections worldwide and is increasingly being recognized as representing a serious threat …

We describe new synthetic routes developed toward a range of substituted analogues of
bromo and extra-terminal (BET) bromodomain inhibitors I-BET762/JQ1 based on the triazolo …