Role of myokines in regulating skeletal muscle mass and function

JH Lee, HS Jun - Frontiers in physiology, 2019 - frontiersin.org
Loss of skeletal muscle mass and strength has recently become a hot research topic with the
extension of life span and an increasingly sedentary lifestyle in modern society …

Myokines and adipokines: Involvement in the crosstalk between skeletal muscle and adipose tissue

F Li, Y Li, Y Duan, CAA Hu, Y Tang, Y Yin - Cytokine & growth factor …, 2017 - Elsevier
Skeletal muscle and adipose tissue are the two largest organs in the body. Skeletal muscle
is an effector organ, and adipose tissue is an organ that stores energy; in addition, they are …

Role of inflammation in muscle homeostasis and myogenesis

D Costamagna, P Costelli… - Mediators of …, 2015 - Wiley Online Library
Skeletal muscle mass is subject to rapid changes according to growth stimuli inducing both
hypertrophy, through increased protein synthesis, and hyperplasia, activating the myogenic …

Terminally modified RNA

T Chakraborty, S Bancel, SG Hoge, A Roy… - US Patent …, 2017 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49447811&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Role of skeletal muscle in insulin resistance and glucose uptake

KE Merz, DC Thurmond - Comprehensive Physiology, 2011 - Wiley Online Library
The skeletal muscle is the largest organ in the body, by mass. It is also the regulator of
glucose homeostasis, responsible for 80% of postprandial glucose uptake from the …

Myokines in skeletal muscle physiology and metabolism: Recent advances and future perspectives

DK Das, ZA Graham, CP Cardozo - Acta Physiologica, 2020 - Wiley Online Library
Myokines are molecules produced and secreted by skeletal muscle to act in an auto‐, para‐
and endocrine manner to alter physiological function of target tissues. The growing number …

Modified polynucleotides for the production of secreted proteins

T Chakraborty, A De Fougerolles - US Patent 9,192,651, 2015 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49235350&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Engineered nucleic acids and methods of use thereof

S Bancel, JP Schrum, A Aristarkhov - US Patent 9,464,124, 2016 - Google Patents
A61K48/0075—Medicinal preparations containing genetic material which is inserted into
cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of …

In vivo production of proteins

S Bancel, T Chakraborty, A De Fougerolles… - US Patent …, 2015 - Google Patents
2013-03-19 Assigned to modeRNA Therapeutics reassignment modeRNA Therapeutics
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …

Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins

T Chakraborty, A De Fougerolles - US Patent 9,303,079, 2016 - Google Patents
2013-03-19 Assigned to modeRNA Therapeutics reassignment modeRNA Therapeutics
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …