Cancer arises following alterations at different cellular levels, including genetic and
epigenetic modifications, transcription and translation dysregulation, as well as metabolic …

Simple Summary Prostate cancer is a heterogeneous disease and a major cause of cancer
deaths worldwide. The most widely used prostate cancer biomarker, prostate-specific …

Prostate cancer (PC) is a significant cause of mortality in men worldwide, hence the need for
a comprehensive understanding of the molecular mechanisms underlying its progression …

Benign prostatic hyperplasia (BPH) is a common condition marked by the enlargement of
the prostate gland, which often leads to significant urinary symptoms and a decreased …

Introduction New potential biomarkers to pre-intervention identification of a clinically
significant prostate cancer (csPCa) will prevent overdiagnosis and overtreatment and limit …

Prostate cancer (PCa) is one of the most commonly diagnosed types of malignancy and is
the second leading cause of cancer-related death in men in developed countries. Cyclin …

Prostate cancer is among the top five cancer types according to incidence and mortality. One
of the main obstacles in prostate cancer management is the inability to foresee its course …

Gleason grading is an important prognostic indicator for prostate adenocarcinoma and is
crucial for patient treatment decisions. However, intermediate-risk patients diagnosed in the …

Identifying indolent and aggressive prostate cancers is a critical problem for optimal
treatment. The existing approaches of prostate cancer detection are facing challenges as the …

Abstract Background The Prostate Cancer Cohort Consortium (PC3) Working Group
proposed a definition for aggressive prostate cancer (PC) for aetiologic epidemiologic …