Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients
and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis …

Adult tissues set the scene for a continuous battle between cells, where a comparison of
cellular fitness results in the elimination of weaker “loser” cells. This phenomenon, named …

Hepatoblastoma, the most prevalent pediatric liver cancer, almost always carries a WNT-
activating CTNNB1 mutation, yet exhibits notable molecular heterogeneity. To characterize …

Hepatocytes, the liver's predominant cells, perform numerous essential biological functions.
However, crucial events and regulators during hepatocyte maturation require in-depth …

The process of metabolic liver zonation is spontaneously established by assigning
distributed tasks to hepatocytes along the porto-central blood flow. Hepatocytes fulfil critical …

Robust regenerative response post liver injuries facilitates the architectural and functional
recovery of the liver. Intrahepatic redox homeostasis plays a key role in liver regeneration. In …

Following severe liver injury, when hepatocyte-mediated regeneration is impaired, biliary
epithelial cells (BECs) can transdifferentiate into functional hepatocytes. However, the …

The roof plate-specific spondin–leucine-rich repeat-containing G-protein coupled receptor
4/5 (LGR4/5)–zinc and ring finger 3 (ZNRF3)/ring finger protein 43 (RNF43) module is a …

Hepatic zonation is critical for most metabolic functions in liver. Wnt signaling plays an
important role in establishing and maintaining liver zonation. Yet, the anatomic expression of …

Liver fibrosis, as a consequence of chronic liver disease, involves the activation of hepatic
stellate cell (HSC) caused by various chronic liver injuries. Emerging evidence suggests that …