RNA-binding proteins (RBPs) play essential roles in coordinating germline gene expression
and development in all organisms. Here, we report that loss of ADR-2, a member of the …

Simple Summary Both extrinsic signaling and intrinsic regulation are critical for maintaining
cellular homeostasis, and their dysregulation is often associated with tumorigenesis and …

During C. elegans development, 1090 somatic cells are generated, of which 959 survive
and 131 die, many through apoptosis. We present evidence that PUF-8, a C. elegans …

Germ cells are uniquely capable of maintaining cellular immortality, allowing them to give
rise to new individuals in generation after generation. Recent studies have identified that the …

Using the nematode C. elegans germline as a model system, we previously reported that
PUF-8 (a PUF RNA-binding protein) and LIP-1 (a dual-specificity phosphatase) repress …

RNA binding proteins play essential roles in coordinating germline gene expression and
development in all organisms. Here, we report that loss of ADR-2, a member of the …

As the average human lifespan continues to increase, cancer remains a major health
concern. 1 The World Health Organization reports cancer as the second leading cause of …

Stem cells are central to the development of multi-cellular organisms, including C. elegans
and humans. Key to their function is their ability to differentiate into more specialized cells or …

Using the nematode C. elegans germline as a model system, we previously reported that
PUF-8 (a PUF RNA-binding protein) and LIP-1 (a dual-specificity phosphatase) repress …

Abstract Conserved PUF (Pumilio and FBF) proteins repress the translation by binding to its
target mRNA 3'untranslated region (3'UTR). C. elegans has 11 PUF proteins. Among them …