Protein tyrosine kinases (PTKs) are a class of proteins with tyrosine kinase activity that
phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal …

Here, we describe an approach to correct the genetic defect in fragile X syndrome (FXS) via
recruitment of endogenous repair mechanisms. A leading cause of autism spectrum …

Nodal peripheral T-cell lymphomas (PTCL) are uncommon and heterogeneous tumors
characterized by a dismal prognosis. Targeted therapy has been proposed. However …

Targeting Anaplastic lymphoma kinase (ALK) is a promising therapeutic strategy for aberrant
ALK-expressing malignancies including neuroblastoma, but resistance to ALK tyrosine …

Children with early relapsed or refractory ALK-positive anaplastic large cell lymphoma
(ALCL) have a high risk of further disease progression during re-induction with intensive …

Abstract Background Anaplastic Large Cell Lymphoma (ALCL) is a rare and aggressive T-
cell lymphoma, classified into ALK-positive and ALK-negative subtypes, based on the …

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase expressed at early stages of
normal development and in various cancers including ALK-positive anaplastic large cell …

Cellular senescence has a complex role in lymphocyte carcinogenesis and drug resistance
of lymphomas. Senescent lymphoma cells combine with immunocytes to create an ageing …

Central nervous system (CNS) involvement in anaplastic large cell lymphoma (ALCL) at
diagnosis is rare and leads to poor prognosis with the use of the standard ALCL99 protocol …

Simple Summary Tyrosine kinase inhibitors (TKIs) targeting anaplastic lymphoma kinase
(ALK), such as crizotinib and alectinib, provide favorable clinical responses in human …