Immune checkpoint inhibitors (ICBs) have revolutionized cancer treatment producing
remarkable and durable responses for a range of malignancies. However, the additional …

Tumor necrosis factor-alpha (TNF-a) is involved in the pathogenesis of several inflammatory
diseases such as rheumatoid arthritis (RA), ankylosing spondylitis, psoriatic arthritis, and …

Immunosuppressive therapies, effective in treating inflammatory disorders such as psoriasis,
increase the risk of serious infections, such as tuberculosis (TB). For example, tumour …

Tumor-necrosis-factor-α inhibitors (anti-TNF-α) are associated with an increased risk of
tuberculosis (TB) disease, primarily due to reactivation of latent TB infection (LTBI). We …

Kidney transplanted patients are a unique population with intrinsic susceptibility to viral and
bacterial infections, mainly (but not exclusively) due to continuous immunosuppression. In …

CLL is associated with an increased risk of infectious complications. Treatment with BTK or
BCL-2 inhibitors does not seem to increase significantly the risk of opportunistic infections …

The destruction of lung parenchyma caused by TB can result in pulmonary sequelae that are
classified as bronchiectasis due to traction (radiological sequelae), and bronchiectasis …

Background Screening for tuberculosis (TB) infection often includes QuantiFERON-TB Gold
Plus (QFT) testing. Previous studies showed that two-thirds of patients with negative QFT …

Screening for latent tuberculosis infection (LTBI) is mandatory before commencing tumor
necrosis factor (TNF)-α inhibitor use. However, the impact of immunosuppressive therapy …

Tuberculosis (TB) is an infectious disease that poses a major health threat and is one of the
leading causes of death worldwide. Following exposure to Mycobacterium tuberculosis (M …