What makes Yarrowia lipolytica well suited for industry?

YK Park, R Ledesma-Amaro - Trends in Biotechnology, 2023 - cell.com
Yarrowia lipolytica possesses natural and engineered traits that make it a good host for the
industrial bioproduction of chemicals, fuels, foods, and pharmaceuticals. In recent years …

Yarrowia lipolytica Strains and Their Biotechnological Applications: How Natural Biodiversity and Metabolic Engineering Could Contribute to Cell Factories …

C Madzak - Journal of Fungi, 2021 - mdpi.com
Among non-conventional yeasts of industrial interest, the dimorphic oleaginous yeast
Yarrowia lipolytica appears as one of the most attractive for a large range of white …

Engineering 4-coumaroyl-CoA derived polyketide production in Yarrowia lipolytica through a β-oxidation mediated strategy

CM Palmer, KK Miller, A Nguyen, HS Alper - Metabolic engineering, 2020 - Elsevier
Polyketides are a diverse class of molecules sought after for their valuable properties,
including as potential pharmaceuticals. Previously, we demonstrated that the oleaginous …

Microbial hosts for metabolic engineering of lignin bioconversion to renewable chemicals

TDH Bugg, JJ Williamson, F Alberti - Renewable and Sustainable Energy …, 2021 - Elsevier
This review discusses the use of engineered microbes for bioconversion of lignin from plant
biomass to produce renewable chemicals. Existing bacterial hosts for lignin bioconversion …

Metabolic engineering of the oleaginous yeast Yarrowia lipolytica PO1f for production of erythritol from glycerol

SS Jagtap, AA Bedekar, V Singh, YS Jin… - Biotechnology for …, 2021 - Springer
Background Sugar alcohols are widely used as low-calorie sweeteners in the food and
pharmaceutical industries. They can also be transformed into platform chemicals. Yarrowia …

Direct production of fatty alcohols from glucose using engineered strains of Yarrowia lipolytica

LT Cordova, J Butler, HS Alper - Metabolic Engineering Communications, 2020 - Elsevier
Fatty alcohols are important industrial oleochemicals with broad applications and a growing
market. Here, we sought to engineer Yarrowia lipolytica to serve as a renewable source of …

Producing Biochemicals in Yarrowia lipolytica from Xylose through a Strain Mating Approach

H Li, HS Alper - Biotechnology Journal, 2020 - Wiley Online Library
Enabling xylose catabolism is challenging, especially for unconventional yeasts and
previously engineered background strains. In this study, the efficacy of a yeast mating …

Identification and Characterization of the Mitochondrial Replication Origin for Stable and Episomal Expression in Yarrowia lipolytica

Z Cui, H Zheng, Z Jiang, Z Wang, J Hou… - ACS synthetic …, 2021 - ACS Publications
Episomal plasmids are crucial expression tools for recombinant protein production and
genome editing. In Saccharomyces cerevisiae, 2-μm artificial plasmids with a high copy …

Recent advances in plasmid-based tools for establishing novel microbial chassis

LC Nora, CA Westmann, ME Guazzaroni… - Biotechnology …, 2019 - Elsevier
A key challenge for domesticating alternative cultivable microorganisms with
biotechnological potential lies in the development of innovative technologies. Within this …

A novel electroporation procedure for highly efficient transformation of Lipomyces starkeyi

H Takaku, A Miyajima, H Kazama, R Sato, S Ara… - Journal of …, 2020 - Elsevier
Microbial lipids produced by oleaginous microorganisms as raw materials for the production
of oleochemicals and biodiesel are sustainable while avoiding competition with food …