The structural basis of antibody-antigen recognition
I Sela-Culang, V Kunik, Y Ofran - Frontiers in immunology, 2013 - frontiersin.org
The function of antibodies (Abs) involves specific binding to antigens (Ags) and activation of
other components of the immune system to fight pathogens. The six hypervariable loops …
other components of the immune system to fight pathogens. The six hypervariable loops …
Molecular mechanisms of action of anti-TNF-α agents–Comparison among therapeutic TNF-α antagonists
H Mitoma, T Horiuchi, H Tsukamoto, N Ueda - Cytokine, 2018 - Elsevier
Tumor necrosis factor (TNF)-α is a potent pro-inflammatory and pathological cytokines in
inflammatory diseases such as rheumatoid arthritis and inflammatory bowel diseases. Anti …
inflammatory diseases such as rheumatoid arthritis and inflammatory bowel diseases. Anti …
[HTML][HTML] High concentration of branched-chain amino acids promotes oxidative stress, inflammation and migration of human peripheral blood mononuclear cells via …
O Zhenyukh, E Civantos, M Ruiz-Ortega… - Free Radical Biology …, 2017 - Elsevier
Leucine, isoleucine and valine are essential aminoacids termed branched-chain amino
acids (BCAA) due to its aliphatic side-chain. In several pathological and physiological …
acids (BCAA) due to its aliphatic side-chain. In several pathological and physiological …
Transmembrane TNF-α: structure, function and interaction with anti-TNF agents
T Horiuchi, H Mitoma, S Harashima… - …, 2010 - academic.oup.com
Transmembrane TNF-α, a precursor of the soluble form of TNF-α, is expressed on activated
macrophages and lymphocytes as well as other cell types. After processing by TNF-α …
macrophages and lymphocytes as well as other cell types. After processing by TNF-α …
Optimized Fc variants
GA Lazar, AJ Chirino, W Dang, JR Desjarlais… - US Patent …, 2008 - Google Patents
2004-11-10 Assigned to XENCOR, INC. reassignment XENCOR, INC. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DANG, WEI …
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DANG, WEI …
Optimized FC variants
GA Lazar, W Dang, JR Desjarlais, SB Karki… - US Patent …, 2012 - Google Patents
2005-09-29 Assigned to XENCOR, INC. reassignment XENCOR, INC. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HAYES, ROBERT …
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HAYES, ROBERT …
Fc variants with altered binding to FcRn
AK Chamberlain, BI Dahiyat, JR Desjarlais… - US Patent …, 2013 - Google Patents
The present application relates to a variant Fc region com prising at least one modification
relative to a wild-type human Fc region, where the modification selected from the group …
relative to a wild-type human Fc region, where the modification selected from the group …
Optimized Fc variants and methods for their generation
GA Lazar, AJ Chirino, W Dang, JR Desjarlais… - US Patent …, 2010 - Google Patents
US7662925B2 - Optimized Fc variants and methods for their generation - Google Patents
US7662925B2 - Optimized Fc variants and methods for their generation - Google Patents …
US7662925B2 - Optimized Fc variants and methods for their generation - Google Patents …
Optimized anti-CD20 monoclonal antibodies having Fc variants
BI Dahiyat, GA Lazar, O Vafa - US Patent 8,084,582, 2011 - Google Patents
US8084582B2 - Optimized anti-CD20 monoclonal antibodies having Fc variants - Google
Patents US8084582B2 - Optimized anti-CD20 monoclonal antibodies having Fc variants …
Patents US8084582B2 - Optimized anti-CD20 monoclonal antibodies having Fc variants …
Immunoglobulin variants outside the Fc region
GA Lazar, SB Karki - US Patent 7,276,585, 2007 - Google Patents
(60) Provisional application No. 60/556,353,? led on Mar. 6'950'754 B2 9/2005 M?“et 31'....
6,982,321 B2 l/2006 Wlnter 24, 2004, prov1s1onal app11cat1on No. 60/573,302, 6992 234 …
6,982,321 B2 l/2006 Wlnter 24, 2004, prov1s1onal app11cat1on No. 60/573,302, 6992 234 …