Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …

Replication stress is a major cause of genomic instability and a crucial vulnerability of
cancer cells. This vulnerability can be therapeutically targeted by inhibiting kinases that …

The inhibition of the DNA damage response (DDR) pathway in the treatment of cancer has
recently gained interest, and different DDR inhibitors have been developed. Among them …

DNA damage response (DDR) pathway prevents high level endogenous and environmental
DNA damage being replicated and passed on to the next generation of cells via an …

Resistance to chemo-and radiotherapy is a common event among cancer patients and a
reason why new cancer therapies and therapeutic strategies need to be in continuous …

Simple Summary Mutations in the tumor suppressor p53 (p53) occur in~ 50% of human
cancers, the majority of which are missense mutations. Mutations in p53 not only impair the …

The concept of 'BRCAness' defines the pathogenesis and vulnerability of multiple cancers.
The canonical definition of BRCAness is a defect in homologous recombination repair …

The DNA damage response (DDR) is now known to play an important role in both cancer
development and its treatment. Targeting proteins such as ATR (Ataxia telangiectasia …

Over the last decades, the growing understanding on DNA damage response (DDR)
pathways has broadened the therapeutic landscape in oncology. It is becoming increasingly …

Synthetic lethality is a lethal phenomenon in which the occurrence of a single genetic event
is tolerable for cell survival, whereas the co-occurrence of multiple genetic events results in …