Noninvasive serum biomarkers for liver fibrosis in NAFLD: current and future

T Reinson, RM Buchanan… - Clinical and molecular …, 2022 - pmc.ncbi.nlm.nih.gov
In the last 20 years, noninvasive serum biomarkers to identify liver fibrosis in patients with
non-alcoholic fatty liver disease (NAFLD) have been developed, validated against liver …

Emerging pharmacological treatment options for MAFLD

Á Rojas, C Lara-Romero… - Therapeutic …, 2022 - journals.sagepub.com
Metabolic dysfunction–associated fatty liver disease (MAFLD) prevalence and incidence is
rising globally. It is associated with metabolic comorbidities, obesity, overweight, type 2 …

Glucagon-like peptide-1 receptor agonist use in patients with liver cirrhosis and type 2 diabetes

FS Yen, MC Hou, JCC Wei, YH Shih, CY Hsu… - Clinical …, 2024 - Elsevier
Background and Aims Liver cirrhosis is often associated with type 2 diabetes (T2D), but
research on treatment of T2D in cirrhotic patients is scarce. We investigated the long-term …

Effect of pharmacological interventions and placebo on liver Histology in nonalcoholic steatohepatitis: A network meta-analysis

G Pennisi, C Celsa, M Enea, M Vaccaro… - Nutrition, Metabolism …, 2022 - Elsevier
Background The aims of this study were to quantify the histological improvement and its risk
factors in patients with NASH enrolled in the placebo arms of randomized controlled trials …

Endpoints in NASH clinical trials: are we blind in one eye?

A Lonardo, S Ballestri, A Mantovani, G Targher, F Bril - Metabolites, 2024 - mdpi.com
This narrative review aims to illustrate the notion that nonalcoholic steatohepatitis (NASH),
recently renamed metabolic dysfunction-associated steatohepatitis (MASH), is a systemic …

Natural history of lean and non-lean metabolic dysfunction-associated steatotic liver disease

SI Wakabayashi, N Tamaki, T Kimura… - Journal of …, 2024 - Springer
Background Conflicting evidence regarding the prognosis of lean metabolic dysfunction-
associated steatotic liver disease (MASLD) has raised substantial questions. Aim This study …

Multi‐omic network analysis identified betacellulin as a novel target of omega‐3 fatty acid attenuation of western diet‐induced nonalcoholic steatohepatitis

J Padiadpu, M Garcia‐Jaramillo… - EMBO Molecular …, 2023 - embopress.org
Clinical and preclinical studies established that supplementing diets with ω3
polyunsaturated fatty acids (PUFA) can reduce hepatic dysfunction in nonalcoholic …

The biochemical pattern defines MASLD phenotypes linked to distinct histology and prognosis

J Ampuero, R Aller, R Gallego-Durán, J Crespo… - Journal of …, 2024 - Springer
Background MASLD can manifest as hepatocellular damage, which can result in mild
elevation of aminotransferases. However, in some patients, MASLD presents with …

NAFLD Fibrosis Progression and Type 2 Diabetes: The Hepatic–Metabolic Interplay

S Cernea - Life, 2024 - mdpi.com
The bidirectional relationship between type 2 diabetes and (non-alcoholic fatty liver disease)
NAFLD is indicated by the higher prevalence and worse disease course of one condition in …

[HTML][HTML] Current Status of Glucagon-like Peptide-1 Receptor Agonists in Metabolic Dysfunction-associated Steatotic Liver Disease: A Clinical Perspective

MW Wang, LG Lu - Journal of Clinical and Translational …, 2024 - pmc.ncbi.nlm.nih.gov
Metabolic dysfunction-associated steatotic liver disease (MASLD) is currently a pressing
public health issue associated with adverse outcomes such as cirrhosis, malignancy …