Integrins are transmembrane receptors that have been implicated in the biology of various
human physiological and pathological processes. These molecules facilitate cell …

Breast cancer remains to be a dreadful disease even with several advancements in
radiation and chemotherapies, owing to the drug resistance and tumor relapse caused by …

The current view is that breast cancer is a stem cell disease characterized by the existence
of cancer cells with stem-like features and tumor-initiating potential. These cells are made …

Abstract Rationale: Cancer stem cells (CSCs) are considered to be essential for
tumorigenesis, recurrence, and metastasis and therefore serve as a biomarker for tumor …

Recent advances in research on cancer have led to understand the pathogenesis of cancer
and development of new anticancer drugs. Despite of these advancements, many tumors …

Background Ovarian cancer has the highest ratio of mortality among gynecologic
malignancies. Chemotherapy is one of the most common treatment options for ovarian …

The Wnt, Hedgehog, and Notch pathways are inherent signaling pathways in normal
embryogenesis, development, and hemostasis. However, dysfunctions of these pathways …

Ferroptosis, which is characterized by intracellular iron accumulation and lipid peroxidation,
is a newly described form of regulated cell death that may play a key role in tumour …

Fascin is a pro-metastatic actin-bundling protein that is upregulated in all metastatic
carcinomas. Fascin promotes cancer cell migration and invasion by facilitating membrane …

Fascin actin-bundling protein 1 (FSCN1) is a highly conserved actin-bundling protein that
cross links F-actin microfilaments into tight, parallel bundles. Elevated FSCN1 levels have …