Glucose is the key source for most organisms to provide energy, as well as the key source
for metabolites to generate building blocks in cells. The deregulation of glucose …

The p53 family of transcription factors is essential to counteract tumour formation and
progression. Although previously this was exclusively associated with the ability of the p53 …

Purpose: The oncogenic miR-155 is upregulated in many human cancers, and its
expression is increased in more aggressive and therapy-resistant tumors, but the molecular …

The tumor suppressor p53 when undergoes amyloid formation confers several gain-of-
function (GOF) activities that affect molecular pathways crucial for tumorigenesis and …

Metastasis is one of the most challenging issues in cancer patient management, and
effective therapies to specifically target disease progression are missing, emphasizing the …

Background Interferon-γ (IFN-γ) is a key cytokine with diverse biological functions, including
antiviral defense, antitumor activity, immune regulation, and modulation of cellular …

Distinct lung stem cells give rise to lung adenocarcinoma (LUAD) and squamous cell
carcinoma (LUSC). ΔNp63, the p53 family member and p63 isoform, guides the maturation …

Cancer progression to metastatic stages is still unmanageable and the promise of effective
anti-metastatic therapy remains largely unmet, emphasizing the need to develop novel …

TP53-induced glycolysis and apoptosis regulator (TIGAR) is a p53 target protein that plays
critical roles in glycolysis and redox balance. Accumulating evidence shows that TIGAR is …

Cervical cancer (CC) is one of most common malignancies affecting women worldwide. To
date, surgical resection is the only effective radical remedy for CC at its early stages, while …