Tissues are dynamically shaped by bidirectional communication between resident cells and
the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling …

Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …

Liver fibrosis and in particular cirrhosis are the major causes of morbidity and mortality of
patients with chronic liver disease. Their prevention or reversal have become major …

Liver fibrosis is a substantial risk factor for the development and progression of liver cancer,
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …

Liver metastases remain a major barrier to successful management of malignant disease,
particularly for cancers of the gastrointestinal tract but also for other malignancies, such as …

Almost all human cancers display dysregulated expression and/or function of one or more
receptor tyrosine kinases (RTKs). The strong causative association between altered RTK …

Liver metastasis (LM) severely affects gastric cancer (GC) patients' prognosis. Small
extracellular vesicles (sEVs) play key roles in intercellular communication. Specific sEV …

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third
leading cause of cancer death. Recent epidemiological data indicate that the mortality rate …

The extracellular matrix critically controls cancer cell behavior by inducing several signaling
pathways through cell membrane receptors. Besides conferring structural properties to …

Stellate cells are resident lipid-storing cells of the pancreas and liver that transdifferentiate to
a myofibroblastic state in the context of tissue injury. Beyond having roles in tissue …