The computational prediction of drug responses based on the analysis of multiple types of
genome-wide molecular data is vital for accomplishing the promise of precision medicine in …

Drug discovery is important in cancer therapy and precision medicines. Traditional
approaches of drug discovery are mainly based on in vivo animal experiments and in vitro …

Objective Drug combination screening has advantages in identifying cancer treatment
options with higher efficacy without degradation in terms of safety. A key challenge is that the …

Obtaining accurate drug response data in large cohorts of cancer patients is very
challenging; thus, most cancer pharmacogenomics discovery is conducted in preclinical …

There is cumulating evidence that in vitro 3D tumor models with increased physiological
relevance can improve the predictive value of pre‐clinical research and ultimately contribute …

Conventional techniques for in vitro cancer drug screening require labor-intensive formalin
fixation, paraffin embedding, and dye staining of tumor tissues at fixed endpoints. This way …

Introduction: Elevated tumor interstitial fluid pressure (TIFP) is a major barrier to successful
cancer treatment. It is mainly caused by an inadequate tumor perfusion resulting from …

Combinatorial therapeutic approaches are an imperative to improve cancer treatment,
because it is critical to impede compensatory signaling mechanisms that can engender drug …

Bisindole alkaloids are a source of inspiration for the design and discovery of new-
generation anticancer agents. In this study, we investigated the cytotoxic and …

Natural products remain a significant source of anticancer chemotherapeutics. The search
for targeted drugs for cancer treatment includes consideration of natural products, which …