Molecular mechanisms in autoimmune thyroid disease

H Vargas-Uricoechea - Cells, 2023 - mdpi.com
The most common cause of acquired thyroid dysfunction is autoimmune thyroid disease,
which is an organ-specific autoimmune disease with two presentation phenotypes …

Genetic susceptibility to autoimmune thyroid disease: past, present, and future

Y Tomer - Thyroid, 2010 - liebertpub.com
Background: Autoimmune thyroid diseases (AITD), including Graves' disease and
Hashimoto's thyroiditis, arise due to complex interactions between environmental and …

The etiology of autoimmune thyroid disease: a story of genes and environment

Y Tomer, A Huber - Journal of autoimmunity, 2009 - Elsevier
Autoimmune thyroid diseases (AITDs), including Graves' disease (GD) and Hashimoto's
thyroiditis (HT) are prevalent autoimmune diseases, affecting up to 5% of the general …

Hashimoto's thyroiditis: from genes to the disease

K Zaletel, S Gaberscek - Current genomics, 2011 - ingentaconnect.com
Hashimoto's thyroiditis (HT) is the most prevalent autoimmune thyroid disorder. Intrathyroidal
lymphocytic infiltration is followed by a gradual destruction of the thyroid gland which may …

Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms

A Huber, F Menconi, S Corathers… - Endocrine …, 2008 - academic.oup.com
Abstract Type 1 diabetes (T1D) and autoimmune thyroid diseases (AITD) frequently occur
together within families and in the same individual. The co-occurrence of T1D and AITD in …

Thyrotropin receptor–associated diseases: from adenomata to Graves disease

TF Davies, T Ando, RY Lin, Y Tomer… - The Journal of clinical …, 2005 - Am Soc Clin Investig
The thyroid-stimulating hormone receptor (TSHR) is a G protein–linked, 7–transmembrane
domain (7-TMD) receptor that undergoes complex posttranslational processing unique to …

The CD40, CTLA-4, thyroglobulin, TSH receptor, and PTPN22 gene quintet and its contribution to thyroid autoimmunity: back to the future

EM Jacobson, Y Tomer - Journal of autoimmunity, 2007 - Elsevier
Autoimmune thyroid diseases (AITD) are common autoimmune diseases, affecting up to 5%
of the general population. Thyroid-directed autoimmunity is manifested in two classical …

The genetics of psoriasis and autoimmunity

AM Bowcock - Annu. Rev. Genomics Hum. Genet., 2005 - annualreviews.org
▪ Abstract Psoriasis is an inflammatory/autoimmune disease and, as with many autoimmune
diseases, is associated with alleles from the major histocompatibility complex (MHC). With …

The genetic basis of thyroid autoimmunity

EM Jacobson, Y Tomer - Thyroid, 2007 - liebertpub.com
Autoimmune thyroid diseases (AITDs), including Graves' disease (GD) and Hashimoto's
thyroiditis (HT), are prevalent autoimmune diseases, affecting up to 5% of the general …

The regulatory T cell gene FOXP3 and genetic susceptibility to thyroid autoimmunity: an association analysis in Caucasian and Japanese cohorts

Y Ban, T Tozaki, T Tobe, Y Ban, EM Jacobson… - Journal of …, 2007 - Elsevier
FOXP3 is a key gene in the development of regulatory T cells (Treg). FOXP3 expression
commits naïve T cells to become Treg cells. Indeed, mutations in the FOXP3 gene cause …