SGLT2 inhibitors: mechanisms of cardiovascular benefit beyond glycaemic control
Abstract Sodium–glucose cotransporter 2 (SGLT2) inhibitors are effective antidiabetic
therapies in patients with type 2 diabetes mellitus and are associated with improved …
therapies in patients with type 2 diabetes mellitus and are associated with improved …
Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart …
Heart failure (HF) is growing to a modern epidemic and despite advances in therapy, it still
carries an ominous prognosis and a significant socioeconomic burden. 1 Many novel agents …
carries an ominous prognosis and a significant socioeconomic burden. 1 Many novel agents …
Extraglycemic effects of SGLT2 inhibitors: a review of the evidence
BM Bonora, A Avogaro, GP Fadini - Diabetes, Metabolic Syndrome …, 2020 - Taylor & Francis
Patients with type 2 diabetes (T2D) are often overweight/obese and affected by arterial
hypertension, dyslipidaemia, and have high serum levels of uric acid. Moreover, T2D patient …
hypertension, dyslipidaemia, and have high serum levels of uric acid. Moreover, T2D patient …
Treatments targeting inotropy: a position paper of the Committees on Translational Research and Acute Heart Failure of the Heart Failure Association of the European …
Acute heart failure (HF) and in particular, cardiogenic shock are associated with high
morbidity and mortality. A therapeutic dilemma is that the use of positive inotropic agents …
morbidity and mortality. A therapeutic dilemma is that the use of positive inotropic agents …
Reno-and cardioprotective molecular mechanisms of SGLT2 inhibitors beyond glycemic control: from bedside to bench
X Chen, CF Hocher, L Shen… - American Journal of …, 2023 - journals.physiology.org
Large placebo-controlled clinical trials have shown that sodium-glucose cotransporter-2
inhibitors (SGLT2i) delay the deterioration of renal function and reduce cardiovascular …
inhibitors (SGLT2i) delay the deterioration of renal function and reduce cardiovascular …
Cardiac effects of SGLT2 inhibitors: the sodium hypothesis
E Bertero, L Prates Roma, P Ameri… - Cardiovascular …, 2018 - academic.oup.com
The effects of intense glycaemic control on macrovascular complications in patients with
type 2 diabetes are incompletely resolved, and many glucose-lowering medications …
type 2 diabetes are incompletely resolved, and many glucose-lowering medications …
SGLT2 inhibitors play a salutary role in heart failure via modulation of the mitochondrial function
Y Maejima - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Three cardiovascular outcome trials of sodium glucose cotransporter 2 (SGLT2) inhibitors,
including the EMPA-REG OUTCOME trial, CANVAS Program, and DECLARE TIMI 58 trial …
including the EMPA-REG OUTCOME trial, CANVAS Program, and DECLARE TIMI 58 trial …
Azithromycin causes a novel proarrhythmic syndrome
Z Yang, JK Prinsen, KR Bersell, W Shen… - Circulation …, 2017 - Am Heart Assoc
Background—The widely used macrolide antibiotic azithromycin increases risk of
cardiovascular and sudden cardiac death, although the underlying mechanisms are unclear …
cardiovascular and sudden cardiac death, although the underlying mechanisms are unclear …
β-adrenergic regulation of late Na+ current during cardiac action potential is mediated by both PKA and CaMKII
Abstract Late Na+ current (I NaL) significantly contributes to shaping cardiac action
potentials (APs) and increased I NaL is associated with cardiac arrhythmias. β-adrenergic …
potentials (APs) and increased I NaL is associated with cardiac arrhythmias. β-adrenergic …
TRPV4 increases cardiomyocyte calcium cycling and contractility yet contributes to damage in the aged heart following hypoosmotic stress
JL Jones, D Peana, AB Veteto… - Cardiovascular …, 2019 - academic.oup.com
Abstract Aims Cardiomyocyte Ca2+ homeostasis is altered with aging via poorly-understood
mechanisms. The Transient Receptor Potential Vanilloid 4 (TRPV4) ion channel is an …
mechanisms. The Transient Receptor Potential Vanilloid 4 (TRPV4) ion channel is an …