The tubulin code in microtubule dynamics and information encoding

A Roll-Mecak - Developmental cell, 2020 - cell.com
Microtubules are non-covalent mesoscale polymers central to the eukaryotic cytoskeleton.
Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin …

Microtubules and microtubule-associated proteins

HV Goodson, EM Jonasson - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Microtubules act as “railways” for motor-driven intracellular transport, interact with accessory
proteins to assemble into larger structures such as the mitotic spindle, and provide an …

Control of microtubule organization and dynamics: two ends in the limelight

A Akhmanova, MO Steinmetz - Nature reviews Molecular cell biology, 2015 - nature.com
Microtubules have fundamental roles in many essential biological processes, including cell
division and intracellular transport. They assemble and disassemble from their two ends …

Electrostatics of nanosystems: application to microtubules and the ribosome

NA Baker, D Sept, S Joseph, MJ Holst… - Proceedings of the …, 2001 - National Acad Sciences
Evaluation of the electrostatic properties of biomolecules has become a standard practice in
molecular biophysics. Foremost among the models used to elucidate the electrostatic …

Microtubule polymerization dynamics

A Desai, TJ Mitchison - Annual review of cell and …, 1997 - annualreviews.org
▪ Abstract The polymerization dynamics of microtubules are central to their biological
functions. Polymerization dynamics allow microtubules to adopt spatial arrangements that …

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.

DN Drechsel, AA Hyman, MH Cobb… - Molecular biology of …, 1992 - Am Soc Cell Biol
Microtubule-associated proteins (MAP), such as tau, modulate the extent and rate of
microtubule assembly and play an essential role in morphogenetic processes, such as …

Drugs that target dynamic microtubules: a new molecular perspective

RA Stanton, KM Gernert, JH Nettles… - Medicinal research …, 2011 - Wiley Online Library
Microtubules have long been considered an ideal target for anticancer drugs because of the
essential role they play in mitosis, forming the dynamic spindle apparatus. As such, there is …

[图书][B] Cell movements: from molecules to motility

D Bray - 2000 - taylorfrancis.com
Cell Movements vividly describes how complex movements can arise from the properties
and behaviors of biological molecules. This second edition is updated throughout with …

Death through a tragedy: mitotic catastrophe

H Vakifahmetoglu, M Olsson… - Cell Death & Differentiation, 2008 - nature.com
Mitotic catastrophe (MC) has long been considered as a mode of cell death that results from
premature or inappropriate entry of cells into mitosis and can be caused by chemical or …

Cytoskeletal dynamics and transport in growth cone motility and axon guidance

EW Dent, FB Gertler - Neuron, 2003 - cell.com
Recent studies indicate the actin and microtubule cytoskeletons are a final common target of
many signaling cascades that influence the developing neuron. Regulation of polymer …