Structural evolution and translational potential for agonists and antagonists of endosomal toll-like receptors
Toll-like receptors (TLRs) are members of a large family of evolutionarily conserved pattern
recognition receptors (PRRs), which serve as key components of the innate immune system …
recognition receptors (PRRs), which serve as key components of the innate immune system …
Development, optimization, and in vivo validation of new imidazopyridine chemotypes as dual TLR7/TLR9 antagonists through activity-directed sequential …
Undesirable activation of endosomal toll-like receptors TLR7 and TLR9 present in specific
immune cells in response to host-derived ligands is implicated in several autoimmune …
immune cells in response to host-derived ligands is implicated in several autoimmune …
Integration of Ligand-Based and Structure-Based Methods for the Design of Small-Molecule TLR7 Antagonists
Toll-like receptor 7 (TLR7) is activated in response to the binding of single-stranded RNA. Its
over-activation has been implicated in several autoimmune disorders, and thus, it is an …
over-activation has been implicated in several autoimmune disorders, and thus, it is an …
Activity-guided development of potent and selective toll-like receptor 9 antagonists
TLR9 is one of the major innate immune receptors expressed in the endosomes of pDCs
and B cells in humans. Aberrant TLR9 activation is implicated in several autoimmune and …
and B cells in humans. Aberrant TLR9 activation is implicated in several autoimmune and …