The eukaryotic initiation factor 4G2 (eIF4G2, DAP5, Nat1, p97) was discovered in 1997. Over
the past two decades, dozens of papers have presented contradictory data on eIF4G2 …

The outbreak of a novel coronavirus SARS-CoV-2 responsible for the COVID-19 pandemic
has caused a worldwide public health emergency. Due to the constantly evolving nature of …

Ocular lens development entails epithelial to fiber cell differentiation, defects in which cause
congenital cataracts. We report the first single-cell multiomic atlas of lens development …

The vertebrate lens is a valuable model system for investigating the gene expression
changes that coordinate tissue differentiation due to its inclusion of two spatially separated …

Epithelial cells and differentiated fiber cells represent distinct compartments in the ocular
lens. While previous studies have revealed proteins that are preferentially expressed in …

Infantile and childhood-onset cataracts form a heterogeneous group of disorders; among the
many genetic causes, numerous pathogenic variants in additional genes associated with …

High-throughput, massively parallel sequence analysis has revolutionized the way that
researchers design and execute scientific investigations. Vast amounts of sequence data …

Recent developments in our understanding of the interactions between long non-coding
RNAs (lncRNAs) and cellular components have improved treatment approaches for various …

The neuromuscular junction (NMJ) is a prototypic chemical synapse between the spinal
motor neuron and the motor endplate. Gene expression profiles of the motor endplate are …

Cataract-associated gene discovery in human and animal models have informed on key
aspects of human lens development, homeostasis and pathology. Additionally, in vitro …