The acquisition of ligand‐independent ESR1 mutations during aromatase inhibitor therapy
in metastatic estrogen receptor (ER)‐positive breast cancer is a common mechanism of …

Approximately 70% of breast cancers are oestrogen receptor α (ER) positive, and are,
therefore, treated with endocrine therapies. However, about 25% of patients with primary …

A myriad of physiological processes in mammals are influenced by estrogens and the
estrogen receptors (ERs), ERα and ERβ. As we reviewed previously, given the widespread …

Estrogen signaling pathways, because of their central role in regulating the growth and
survival of breast tumor cells, have been identified as suitable and efficient targets for cancer …

The most commonly diagnosed breast cancer (BC) subtype is characterized by estrogen
receptor (ER) expression. Treatment of this BC subtype typically involves modalities that …

The idea that somatic ERα mutations could play an important role in the evolution of
hormone-dependent breast cancers was proposed some years ago (Fuqua J Mammary …

Oestrogen receptors are overexpressed in around 70% of all breast cancers, and are a
target for endocrine therapy. These receptors can be visualised on PET with use of 16α-[18 …

Nuclear receptors (NR) impact a myriad of physiological processes including homeostasis,
reproduction, development, and metabolism. NRs are regulated by post-translational …

Simple Summary Estrogens, belonging to a group of steroid compounds, play an important
role in both physiological and disease processes, mainly by interacting with estrogen …

Estrogens play a crucial role in regulating the growth and differentiation of breast cancers,
with approximately two thirds of all breast tumors expressing the estrogen receptor alpha …