Primary lymphoedema

P Brouillard, MH Witte, RP Erickson… - Nature reviews Disease …, 2021 - nature.com
Lymphoedema is the swelling of one or several parts of the body owing to lymph
accumulation in the extracellular space. It is often chronic, worsens if untreated, predisposes …

Intestinal lymphatic vasculature: structure, mechanisms and functions

J Bernier-Latmani, TV Petrova - Nature reviews Gastroenterology & …, 2017 - nature.com
The mammalian intestine is richly supplied with lymphatic vasculature, which has functions
ranging from maintenance of interstitial fluid balance to transport of antigens, antigen …

The lymphatic system in disease processes and cancer progression

TP Padera, EFJ Meijer, LL Munn - Annual review of biomedical …, 2016 - annualreviews.org
Advances in our understanding of the structure and function of the lymphatic system have
made it possible to identify its role in a variety of disease processes. Because it is involved …

Vascular endothelial cell specification in health and disease

C Marziano, G Genet, KK Hirschi - Angiogenesis, 2021 - Springer
There are two vascular networks in mammals that coordinately function as the main supply
and drainage systems of the body. The blood vasculature carries oxygen, nutrients …

Targeting angiogenesis and lymphangiogenesis in kidney disease

K Tanabe, J Wada, Y Sato - Nature Reviews Nephrology, 2020 - nature.com
The kidney is permeated by a highly complex vascular system with glomerular and
peritubular capillary networks that are essential for maintaining the normal functions of …

Biology of vascular endothelial growth factor C in the morphogenesis of lymphatic vessels

K Rauniyar, SK Jha, M Jeltsch - Frontiers in bioengineering and …, 2018 - frontiersin.org
Because virtually all tissues contain blood vessels, the importance of hemevascularization
has been long recognized in regenerative medicine and tissue engineering. However, the …

[HTML][HTML] Clinical application of genome and exome sequencing as a diagnostic tool for pediatric patients: a scoping review of the literature

HS Smith, JM Swint, SR Lalani, JM Yamal… - Genetics in …, 2019 - Elsevier
Purpose Availability of clinical genomic sequencing (CGS) has generated questions about
the value of genome and exome sequencing as a diagnostic tool. Analysis of reported CGS …

Update and audit of the St George's classification algorithm of primary lymphatic anomalies: a clinical and molecular approach to diagnosis

K Gordon, R Varney, V Keeley, K Riches… - Journal of Medical …, 2020 - jmg.bmj.com
Primary lymphatic anomalies may present in a myriad of ways and are highly heterogenous.
Careful consideration of the presentation can lead to an accurate clinical and/or molecular …

[HTML][HTML] Dysregulation of lymphatic endothelial VEGFR3 signaling in disease

K Kuonqui, AC Campbell, A Sarker, A Roberts… - Cells, 2023 - mdpi.com
Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR3), a receptor tyrosine kinase
encoded by the FLT4 gene, plays a significant role in the morphogenesis and maintenance …

Loss of ADAMTS3 activity causes Hennekam lymphangiectasia–lymphedema syndrome 3

P Brouillard, L Dupont, R Helaers… - Human Molecular …, 2017 - academic.oup.com
Primary lymphedema is due to developmental and/or functional defects in the lymphatic
system. It may affect any part of the body, with predominance for the lower extremities …