A comprehensive review of autophagy and its various roles in infectious, non-infectious, and lifestyle diseases: current knowledge and prospects for disease …

R Khandia, M Dadar, A Munjal, K Dhama, K Karthik… - Cells, 2019 - mdpi.com
Autophagy (self-eating) is a conserved cellular degradation process that plays important
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …

S‐adenosylmethionine: a metabolite critical to the regulation of autophagy

Y Ouyang, Q Wu, J Li, S Sun, S Sun - Cell proliferation, 2020 - Wiley Online Library
Autophagy is a mechanism that enables cells to maintain cellular homeostasis by removing
damaged materials and mobilizing energy reserves in conditions of starvation. Although …

Toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-I-like receptors (RLRs) in innate immunity. TLRs, NLRs, and RLRs ligands as immunotherapeutic …

K Wicherska-Pawłowska, T Wróbel… - International journal of …, 2021 - mdpi.com
The innate immune system plays a pivotal role in the first line of host defense against
infections and is equipped with patterns recognition receptors (PRRs) that recognize …

The Tumor Suppressor PTEN as Molecular Switch Node Regulating Cell Metabolism and Autophagy: Implications in Immune System and Tumor Microenvironment

S Aquila, M Santoro, A Caputo, ML Panno, V Pezzi… - Cells, 2020 - mdpi.com
Recent studies conducted over the past 10 years evidence the intriguing role of the tumor
suppressor gene Phosphatase and Tensin Homolog deleted on Chromosome 10 PTEN in …

Network analysis and transcriptome profiling identify autophagic and mitochondrial dysfunctions in SARS-CoV-2 infection

K Singh, YC Chen, S Hassanzadeh, K Han… - Frontiers in …, 2021 - frontiersin.org
Analyzing host cells' transcriptional response to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection will help delineate biological processes underlying …

HSPA8/HSC70 in immune disorders: a molecular rheostat that adjusts chaperone-mediated autophagy substrates

SR Bonam, M Ruff, S Muller - Cells, 2019 - mdpi.com
HSPA8/HSC70 is a molecular chaperone involved in a wide variety of cellular processes. It
plays a crucial role in protein quality control, ensuring the correct folding and re-folding of …

Breast milk-derived extracellular vesicles enriched in exosomes from mothers with type 1 diabetes contain aberrant levels of microRNAs

AH Mirza, S Kaur, LB Nielsen, J Størling… - Frontiers in …, 2019 - frontiersin.org
The breast milk plays a crucial role in shaping the initial intestinal microbiota and mucosal
immunity of the infant. Interestingly, breastfeeding has proven to be protective against the …

Autophagy in cancer immunotherapy

Y Lei, E Zhang, L Bai, Y Li - Cells, 2022 - mdpi.com
Autophagy is a stress-induced process that eliminates damaged organelles and
dysfunctional cargos in cytoplasm, including unfolded proteins. Autophagy is involved in …

[HTML][HTML] Gut microbiota-derived short-chain fatty acids promote prostate cancer progression via inducing cancer cell autophagy and M2 macrophage polarization

Y Liu, Q Zhou, F Ye, C Yang, H Jiang - Neoplasia, 2023 - Elsevier
We have previously demonstrated abnormal gut microbial composition in castration-
resistant prostate cancer (CRPC) patients, here we revealed the mechanism of gut …

Crosstalk between autophagy and the cGAS–STING signaling pathway in type I interferon production

K Zhang, S Wang, H Gou, J Zhang, C Li - Frontiers in Cell and …, 2021 - frontiersin.org
Innate immunity is the front-line defense against infectious microorganisms, including
viruses and bacteria. Type I interferons are pleiotropic cytokines that perform antiviral …