Physical activity has been known as an essential element to promote human health for
centuries. Thus, exercise intervention is encouraged to battle against sedentary lifestyle …

With global population aging, age-related diseases, especially sarcopenia, have attracted
much attention in recent years. Characterized by low muscle strength, low muscle quantity or …

Myocardial infarction (MI)-induced heart failure (HF) is commonly accompanied with
profound effects on skeletal muscle. With the process of MI-induced HF, perturbations in …

Skeletal muscle fibers possess, like all cells of our body, an evolutionary conserved
autophagy machinery, which allows them to segregate unfolded proteins and damaged …

Mitochondrial dysfunction may play a crucial role in various diseases due to its roles in the
regulation of energy production and cellular metabolism. Serine/threonine kinase (AKT) is a …

Sarcopenia, a disorder characterized by age-related muscle loss and reduced muscle
strength, is associated with decreased individual independence and quality of life, as well as …

Sarcopenia is a debilitating skeletal muscle disease that accelerates in the last decades of
life and is characterized by marked deficits in muscle strength, mass, quality, and metabolic …

Life expectancy has increased substantially over the last 150 years. Yet this means that now
most people also spend a greater length of time suffering from various age-associated …

The mammalian target of rapamycin (mTOR) is a major regulator of skeletal myocyte
viability. The signaling pathways triggered by mTOR vary according to the type of …

It is estimated that, at minimum, 500 million individuals suffer from cellular metabolic
dysfunction, such as diabetes mellitus (DM), throughout the world. Even more concerning is …