Life of RISC: Formation, action, and degradation of RNA-induced silencing complex

H Iwakawa, Y Tomari - Molecular cell, 2022 - cell.com
Small RNAs regulate a wide variety of biological processes by repressing the expression of
target genes at the transcriptional and post-transcriptional levels. To achieve these …

Towards a molecular understanding of microRNA-mediated gene silencing

S Jonas, E Izaurralde - Nature reviews genetics, 2015 - nature.com
MicroRNAs (miRNAs) are a conserved class of small non-coding RNAs that assemble with
Argonaute proteins into miRNA-induced silencing complexes (miRISCs) to direct post …

The functions of microRNAs: mRNA decay and translational repression

H Iwakawa, Y Tomari - Trends in cell biology, 2015 - cell.com
MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs, which regulate
complementary mRNAs by inducing translational repression and mRNA decay. Although …

The complexity of miRNA-mediated repression

A Wilczynska, M Bushell - Cell Death & Differentiation, 2015 - nature.com
Since their discovery 20 years ago, miRNAs have attracted much attention from all areas of
biology. These short (∼ 22 nt) non-coding RNA molecules are highly conserved in evolution …

The Ccr4‐Not complex is a key regulator of eukaryotic gene expression

MA Collart - Wiley Interdisciplinary Reviews: RNA, 2016 - Wiley Online Library
The Ccr4‐Not complex is a multisubunit complex present in all eukaryotes that contributes to
regulate gene expression at all steps, from production of messenger RNAs (mRNAs) in the …

The intricate balance between microRNA‐induced mRNA decay and translational repression

P Naeli, T Winter, AP Hackett, L Alboushi… - The FEBS …, 2023 - Wiley Online Library
Post‐transcriptional regulation of messenger RNAs (mRNAs)(ie, mechanisms that control
translation, stability and localization) is a critical focal point in spatiotemporal regulation of …

The DEAD-box protein Dhh1p couples mRNA decay and translation by monitoring codon optimality

A Radhakrishnan, YH Chen, S Martin, N Alhusaini… - Cell, 2016 - cell.com
A major determinant of mRNA half-life is the codon-dependent rate of translational
elongation. How the processes of translational elongation and mRNA decay communicate is …

The multiple functions of RNA helicases as drivers and regulators of gene expression

CF Bourgeois, F Mortreux, D Auboeuf - Nature reviews Molecular cell …, 2016 - nature.com
RNA helicases comprise the largest family of enzymes involved in the metabolism of
mRNAs, the processing and fate of which rely on their packaging into messenger …

Mechanistic insights into microRNA-mediated gene silencing

TF Duchaine, MR Fabian - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
MicroRNAs (miRNAs) posttranscriptionally regulate gene expression by repressing protein
synthesis and exert a broad influence over development, physiology, adaptation, and …

MicroRNAs from plants to animals, do they define a new messenger for communication?

Z Li, R Xu, N Li - Nutrition & metabolism, 2018 - Springer
MicroRNAs (miRNAs), a class of single-stranded non-coding RNA of about 22 nucleotides,
are potent regulators of gene expression existing in both plants and animals. Recent studies …