Non-epithelial ovarian cancers (NEOC) are a group of uncommon malignancies that mainly
includes germ cell tumours (GCT), sex cord-stromal tumours (SCST), and some extremely …

Testicular cancer (TC) is the most common solid tumor among men aged between 15 and
40 years. TCs are highly aneuploid and the 12p isochromosome is the most frequent …

Background: Inhibitors targeting programmed cell death 1 (PD-1) and programmed death-
ligand 1 (PD-L1) have unprecedented effects in cancer treatment. However, the objective …

Nonepithelial ovarian cancers (NEOC) are a group of rare malignancies, including germ cell
tumours (GCT) and sex cord-stromal tumours (SCST), along with small-cell carcinomas and …

Testicular cancer is a curable cancer. The success of physicians in curing the disease is
underpinned by multidisciplinary advances. Cisplatin-based combination chemotherapy and …

Background: The immune infiltrate plays an important part in testicular germ cell tumors, but
it remains scarcely studied. We aimed at thoroughly characterizing the immune infiltrate and …

Testicular germ cell tumors (TGCTs) are malignancies with very high curative potential even
in metastatic settings, mainly due to the introduction of cisplatin in the treatment of this …

Testicular germ cell tumors (TGCTs) and sex cord-stromal tumors (SCSTs) are the most
common testicular neoplasms. The morphological spectrum of such tumors is wide, with …

Simple Summary Immune checkpoint inhibitors (ICI) have reshaped treatment paradigms of
multiple solid organ malignancies. In genitourinary malignancies (GU), ICI provide …

Abstract Lessons Learned Advanced germ cell tumors are aggressive and associated with
poor prognosis. Pembrolizumab was overall well tolerated in 12 heavily pretreated patients …