Synthesis of heterocyclic compounds via Michael and Hantzsch reactions

AM Abdella, AM Abdelmoniem… - Journal of …, 2020 - Wiley Online Library
Heterocycles represent the largest diversity of organic compounds with signifcant chemical,
biomedical, and industrial applications. They exist in numerous natural products, dyes, and …

Importance of Hybrid Catalysts toward the Synthesis of 5H-Pyrano[2,3-d]pyrimidine-2-ones/2,4-diones (Thiones)

MP Parmar, RM Vala, HM Patel - ACS omega, 2023 - ACS Publications
The pyranopyrimidine core is a key precursor for medicinal and pharmaceutical industries
due to its broader synthetic applications as well as its bioavailability. Among its four possible …

Hantzsch‐like synthesis, DNA photocleavage, DNA/BSA binding, and molecular docking studies of bis (sulfanediyl) bis (tetrahydro‐5‐deazaflavin) analogs linked to …

MA Ragheb, RE Abdelwahab… - Chemistry & …, 2022 - Wiley Online Library
The cyclocondensation reaction of aldehydes with dimedone and bis (6‐aminopyrimidin‐4‐
one) in acetic acid led to the formation of the corresponding bis (pyrimido [4, 5‐b] quinoline …

Synthesis of novel bis (spirocyclic-2-oxindole)-tethered 10b-azachrysene or 10a-azaphenanthrene systems via a Hantzsch-like reaction

AM Abdelmoniem, IA Abdelhamid, AHM Elwahy… - Tetrahedron, 2024 - Elsevier
The effective synthesis of bis (spirocyclic-2-oxindole) tethered to 10b-azachrysene or 10a-
azaphenanthrene moieties via the Hantzsch-like reaction of phenylenebis (methylene)) bis …

[HTML][HTML] Synthesis of novel star-shaped molecules based on a pentaerythritol core linked to different heterocyclic systems

HM Diab, IA Abdelhamid, ME Salem, I Ragab… - Results in …, 2024 - Elsevier
Synthesis of analogs of known active compounds is the most often employed strategy for
producing important compounds. The Hantzsch reaction was employed to create new star …

[HTML][HTML] Synthesis, molecular docking simulation, and antimicrobial activities of novel bis-heterocycles linked to piperazine and vanillin units as novel hybrid …

IMZ Fares, NE Mahmoud, IA Abdelhamid… - Results in …, 2024 - Elsevier
Bacterial infections are a global issue, causing sickness and death, mainly in developing
nations. Resistance to current medicines is a significant issue in healthcare. Overcoming the …

Efficient Synthesis and Characterization of Novel Pyrido[3′,2′:4,5]thieno[3,2‐d]pyrimidines and Their Fused [1,2,4]triazole Derivatives

SMH Sanad, MAE Hawass, AAM Ahmed… - Journal of …, 2018 - Wiley Online Library
Both 3‐aminothieno [2, 3‐b] pyridine‐2‐carboxamide derivative 4 and bis (3‐aminothieno
[2, 3‐b] pyridine‐2‐carboxamide) derivative 6 are prepared, starting with pyridine‐2 (1H) …

Synthesis of Novel Diphenyl Ether-Based Bis-Heterocycles as Novel Hybrid Molecules via Michael and Other Cyclocondensation Reactions

ME Salem, YA El-Gabry, IA Abdelhamid… - ACS …, 2024 - ACS Publications
Molecular hybridization is a technique used in drug creation that involves combining the
pharmacophoric moieties of multiple bioactive compounds to create a new hybrid molecule …

New Azacycles by One‐Pot Three‐Component Hantzsch‐Like Synthesis of Tetra(hexa)azacyclopenta[a]anthracenes, Tetraazaindeno[5,4‐b]fluorenes, and …

AM Abdelmoniem, MA Ramadan, SAS Ghozlan… - …, 2023 - Wiley Online Library
Abstract New Azacycles by One‐Pot Three‐Component Hantzsch‐Like Synthesis of Tetra
(hexa) azacyclopenta [a] anthracenes, Tetraazaindeno [5, 4‐b] fluorenes, and …

Synthesis, cytotoxicity and molecular docking simulation of novel bis-1, 4-dihydropyridines linked to aliphatic or arene core via amide or ester-amide linkages

AM Abdella, AM Abdelmoniem… - Mini Reviews in …, 2020 - ingentaconnect.com
Objective: Novel bis (1, 4-dihydropyridine-3, 5-dicarbonitrile) derivatives linked to aliphatic
or aromatic cores via amide or ester-amide linkages were prepared and their structures …