Central regulation of food intake is a key mechanism contributing to energy homeostasis.
Many neural circuits that are thought to orchestrate feeding behavior overlap with the brain's …

During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …

The essential role of the brain in maintaining energy homeostasis has motivated the drive to
define the neural circuitry that integrates external and internal stimuli to enact appropriate …

Hypothalamic pro-opiomelanocortin (POMC) neurons promote satiety. Cannabinoid
receptor 1 (CB 1 R) is critical for the central regulation of food intake. Here we test whether …

Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent deacylases that have
traditionally been linked with calorie restriction and aging in mammals. These proteins also …

Calorie or dietary restriction (CR) has attracted attention because it is the oldest and most
robust way to extend rodent life span. The idea that the nutrient sensors, termed sirtuins …

The neural control of appetite is important for understanding motivated behavior as well as
the present rising prevalence of obesity. Over the past several years, new tools for cell type …

We found that leptin receptors were expressed in hypothalamic astrocytes and that their
conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic …

The nervous system evolved to coordinate flexible goal-directed behaviors by integrating
interoceptive and sensory information. Hypothalamic Agrp neurons are known to be crucial …

Reinforcement systems are believed to drive synaptic plasticity within neural circuits that
store memories. Recent evidence from the fruit fly suggests that anatomically distinct …