Sulfur (S VI) based moieties, especially, the sulfonyl or sulfonamide based analogues have
showed a variety of pharmacological properties, and its derivatives propose a high degree …

Azole compounds are an important class of nitrogen heterocycles with electron-rich
property. This special structure endows azole-based derivatives easily bind with the …

Cyclooxygenase-2 is a very important physiological enzyme playing key roles in various
biological functions especially in the mechanism of pain and inflammation, among other …

Major anti-inflammatory agents, steroids and cyclooxygenase, were proved to have serious
side effects. Here, a series of chalcone derivatives were synthesized and screened for anti …

A series of 2-pyrazolines 5–9 have been synthesized from α, β-unsaturated ketones 2–4.
New 2-pyrazoline derivatives 13–15 bearing benzenesulfonamide moieties were then …

Tyrosinase is a copper-containing enzyme that catalyzes the biosynthesis of melanin. This
enzyme is present in bacteria, fungi, plants and animals, and plays multiple roles in …

Pyrazoline is an important five membered nitrogen heterocycle, which has been extensively
researched upon. The ring is quite stable and has inspired chemists to carry out various …

Two groups of coumarin–pyrazoline hybrids were synthesized. The target compounds were
obtained by cyclization of the coumarin chalcones with various substituted hydrazines to …

Chalcones belong to the flavonoid family which constitutes one of the major classes of
naturally occurring oxygen heterocyclic compounds. The α, β-unsaturated carbonyl system …

New pyrazoline derivatives were synthesized and evaluated for their cytotoxic effects on
AsPC-1 human pancreatic adenocarcinoma, U87 and U251 human glioblastoma cell lines …