Several lines of evidence support the view that increased free radical generation and altered
nitric oxide (NO) metabolism play a role in the pathogenesis of highly prevalent ocular …

Background: Uveitis and optic neuritis are prevalent ocular inflammatory diseases, and
highly damaging ocular conditions. Both diseases are currently treated with corticosteroids …

Diabetes is one of the most common metabolic diseases in the world. Vitamin E reduces
protein glycation and improves insulin sensitivity, while cumin is effective in remission of …

purpose. The purpose of the present study was to elucidate the role of the polyol pathway
enzyme aldose reductase (AR) in the mediation of ocular inflammation in a rat model of …

Objective Anecdotal evidence has suggested that guinea pigs have a high prevalence of
ocular lesions. Here we undertook a survey of 1000 guinea pigs from populations of animals …

Since its discovery in mammals as a key-hormone in reproduction and metabolism, leptin
has been identified in an increasing number of tetrapods and teleosts. Tetrapods possess …

Uveitis is a common ophthalmic disorder that can be induced in hamsters by a single
intravitreal injection of bacterial lipopolysaccharide (LPS). To examine the therapeutic …

Purpose Ramelteon (RML) is a potent, selective agonist of the high-affinity melatonin
receptor 1 and 2 receptors. In addition, RML is known to have antioxidant and anti …

AIM To investigate the effect of leptin on the angiogenesis of RF/6A cells (monkey retinal
choroidal endothelial cells) in vitro and test the cellular signaling in the mechanism …

Melatonin is a powerful hormone and antioxidant with numerous effects on the metabolism
and the health of humans. Available as a dietary supplement in the United States since …