Lipids and oocyte developmental competence: the role of fatty acids and β-oxidation

KR Dunning, DL Russell, RL Robker - Reproduction, 2014 - research.monash.edu
Metabolism and ATP levels within the oocyte and adjacent cumulus cells are associated
with quality of oocyte and optimal development of a healthy embryo. Lipid metabolism …

Genetically engineered pigs as models for human disease

C Perleberg, A Kind… - Disease models & …, 2018 - journals.biologists.com
Genetically modified animals are vital for gaining a proper understanding of disease
mechanisms. Mice have long been the mainstay of basic research into a wide variety of …

The use of a fluorescent dye, Nile red, to evaluate the lipid content of single mammalian oocytes

G Genicot, J Leroy, A Van Soom, I Donnay - Theriogenology, 2005 - Elsevier
This study aimed to investigate the use of Nile red, a fluorescent dye specific for intracellular
lipid droplets, to quantify the lipid content of single mammalian oocytes. It was hypothesized …

A role of lipid metabolism during cumulus‐oocyte complex maturation: Impact of lipid modulators to improve embryo production

EG Prates, JT Nunes, RM Pereira - Mediators of inflammation, 2014 - Wiley Online Library
Oocyte intracellular lipids are mainly stored in lipid droplets (LD) providing energy for proper
growth and development. Lipids are also important signalling molecules involved in the …

[HTML][HTML] Effect of vitrification and beta-mercaptoethanol on reactive oxygen species activity and in vitro development of oocytes vitrified before or after in vitro …

MK Gupta, SJ Uhm, HT Lee - Fertility and sterility, 2010 - Elsevier
OBJECTIVE: To investigate the effect of vitrification and beta-mercaptoethanol (β-ME) on
reactive oxygen species (ROS) activity and in vitro development of oocytes vitrified before or …

Enhancement of lipid metabolism with L-carnitine during in vitro maturation improves nuclear maturation and cleavage ability of follicular porcine oocytes

T Somfai, M Kaneda, S Akagi… - Reproduction …, 2011 - CSIRO Publishing
The aim of the present study was to assess the effects of L-carnitine, an enhancer of lipid
metabolism and mitochondrial activity, during in vitro maturation (IVM) on nuclear maturation …

Supplementation of maturation medium with L-carnitine improves cryo-tolerance of bovine in vitro matured oocytes

V Chankitisakul, T Somfai, Y Inaba, M Techakumphu… - Theriogenology, 2013 - Elsevier
The objective was to determine the effects of adding L-carnitine (an enhancer of lipid
metabolism) during IVM, on cryotolerance and developmental competence of bovine …

Homeostatic regulation of lipid droplet content in mammalian oocytes and embryos

M Ibayashi, R Aizawa, J Mitsui, S Tsukamoto - Reproduction, 2021 - rep.bioscientifica.com
Lipid droplets (LDs) consist of a core of neutral lipids such as triacylglycerols and cholesteryl
esters covered by a phospholipid monolayer. Recent studies have shown that LDs not only …

Role of oocyte quality in meiotic maturation and embryonic development

G Marteil, L Richard-Parpaillon, JZ Kubiak - Reproductive biology, 2009 - Elsevier
The quality of oocytes plays a key role in a proper embryo development. In humans, oocytes
of poor quality may be the cause of women infertility and an important obstacle in successful …

Beyond energy provider: multifunction of lipid droplets in embryonic development

T Li, Y Jin, J Wu, Z Ren - Biological Research, 2023 - Springer
Since the discovery, lipid droplets (LDs) have been recognized to be sites of cellular energy
reserves, providing energy when necessary to sustain cellular life activities. Many studies …