Emerging insights into the molecular and cellular basis of glioblastoma

GP Dunn, ML Rinne, J Wykosky… - Genes & …, 2012 - genesdev.cshlp.org
Glioblastoma is both the most common and lethal primary malignant brain tumor. Extensive
multiplatform genomic characterization has provided a higher-resolution picture of the …

An overview of EGFR mechanisms and their implications in targeted therapies for glioblastoma

SMB Rodriguez, A Kamel, GV Ciubotaru… - International Journal of …, 2023 - mdpi.com
Despite all of the progress in understanding its molecular biology and pathogenesis,
glioblastoma (GBM) is one of the most aggressive types of cancers, and without an efficient …

[HTML][HTML] Mining TCGA database for genes of prognostic value in glioblastoma microenvironment

DI Jia, S Li, D Li, H Xue, D Yang, Y Liu - Aging (Albany NY), 2018 - ncbi.nlm.nih.gov
Glioblastoma (GBM) is one of the most deadly brain tumors. The convenient access to The
Cancer Genome Atlas (TCGA) database allows for large-scale global gene expression …

Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2

X Zhou, S Wahane, MS Friedl, M Kluge… - Nature …, 2020 - nature.com
Tissue repair after spinal cord injury requires the mobilization of immune and glial cells to
form a protective barrier that seals the wound and facilitates debris clearing, inflammatory …

The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells

TA Ulrich, EM de Juan Pardo, S Kumar - Cancer research, 2009 - AACR
Glioblastoma multiforme (GBM) is a malignant astrocytoma of the central nervous system
associated with a median survival time of 15 months, even with aggressive therapy. This …

The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance

FA Siebzehnrubl, DJ Silver, B Tugertimur… - EMBO molecular …, 2013 - embopress.org
Glioblastoma remains one of the most lethal types of cancer, and is the most common brain
tumour in adults. In particular, tumour recurrence after surgical resection and radiation …

PPAR-α modulators as current and potential cancer treatments

Y Tan, M Wang, K Yang, T Chi, Z Liao, P Wei - Frontiers in oncology, 2021 - frontiersin.org
Cancer is one of the leading causes of mortality worldwide. PPAR modulators may hold
great potential for the management of cancer patients. Indeed, PPARs are critical sensors …

Glioblastoma, a brief review of history, molecular genetics, animal models and novel therapeutic strategies

S Agnihotri, KE Burrell, A Wolf, S Jalali… - Archivum immunologiae …, 2013 - Springer
Glioblastoma (GBM) is the most common and lethal primary brain tumor. Over the past few
years tremendous genomic and proteomic characterization along with robust animal models …

Astrocytes, the rising stars of the glioblastoma microenvironment

M Brandao, T Simon, G Critchley, G Giamas - Glia, 2019 - Wiley Online Library
Glioblastoma (GBM) is an aggressive primary tumor, causing thousands of deaths
worldwide every year. The mean survival of patients with GBM remains below 20 months …

Elucidating the mechanobiology of malignant brain tumors using a brain matrix-mimetic hyaluronic acid hydrogel platform

B Ananthanarayanan, Y Kim, S Kumar - Biomaterials, 2011 - Elsevier
Glioblastoma multiforme (GBM) is a malignant brain tumor characterized by diffuse
infiltration of single cells into the brain parenchyma, which is a process that relies in part on …