Mesenchymal stem cell-derived extracellular vesicles: An emerging diagnostic and therapeutic biomolecules for neurodegenerative disabilities

M Kandeel, MA Morsy, KM Alkhodair, S Alhojaily - Biomolecules, 2023 - mdpi.com
Mesenchymal stem cells (MSCs) are a type of versatile adult stem cells present in various
organs. These cells give rise to extracellular vesicles (EVs) containing a diverse array of …

[HTML][HTML] Brain incoming call from glia during neuroinflammation: Roles of extracellular vesicles

F D'Egidio, V Castelli, M d'Angelo, F Ammannito… - Neurobiology of …, 2024 - Elsevier
The functionality of the central nervous system (CNS) relies on the connection, integration,
and the exchange of information among neural cells. The crosstalk among glial cells and …

Optimization of extracellular vesicle isolation and their separation from lipoproteins by size exclusion chromatography

B Benayas, J Morales, C Egea… - Journal of …, 2023 - Wiley Online Library
Interest in the use of extracellular vesicles (EVs) as biomarkers of disease is rapidly growing.
However, one main unsolved issue in the EV field is finding a technique able to eliminate …

[HTML][HTML] Brain and immune system-derived extracellular vesicles mediate regulation of complement system, extracellular matrix remodeling, brain repair and antigen …

GT Iglesias, M Fernández-Fournier, L Botella… - Brain, Behavior, and …, 2023 - Elsevier
Background Multiple sclerosis (MS) is an immune-mediated central nervous system disease
whose course is unpredictable. Finding biomarkers that help to better comprehend the …

A scoping review on body fluid biomarkers for prognosis and disease activity in patients with multiple sclerosis

N Barizzone, M Leone, A Pizzino, I Kockum… - Journal of Personalized …, 2022 - mdpi.com
Multiple sclerosis (MS) is a complex demyelinating disease of the central nervous system,
presenting with different clinical forms, including clinically isolated syndrome (CIS), which is …

Proof of concept of using a membrane-sensing peptide for sEVs affinity-based isolation

B Benayas, J Morales, A Gori, A Strada… - … in Bioengineering and …, 2023 - frontiersin.org
Introduction: One main limitation in biomarker studies using EVs is the lack of a suitable
isolation method rendering high yield and purity samples in a quick and easily standardized …

Dual role of peripheral B cells in multiple sclerosis: emerging remote players in demyelination and novel diagnostic biomarkers

G Torres Iglesias, M Fernández-Fournier… - Frontiers in …, 2023 - frontiersin.org
Introduction Multiple sclerosis is an inflammatory and demyelinating disease caused by a
pathogenic immune response against the myelin sheath surfaces of oligodendrocytes. The …

[HTML][HTML] Exosomes and microvesicles in kidney transplantation: the long road from trash to gold

L Ramalhete, R Araújo, A Ferreira, CRC Calado - Pathology, 2024 - Elsevier
Kidney transplantation significantly enhances the survival rate and quality of life of patients
with end-stage kidney disease. The ability to predict post-transplantation rejection events in …

NLRP3 inflammasome in vascular disease: A recurrent villain to combat pharmacologically

A González-Moro, I Valencia, L Shamoon… - Antioxidants, 2022 - mdpi.com
Despite the great advances in medicine, mortality from cardiovascular diseases keeps on
growing. This tendency is not likely to change considering the pandemic proportions of …

Extracellular vesicles released by genetically modified macrophages activate autophagy and produce potent neuroprotection in mouse model of lysosomal storage …

N El-Hage, MJ Haney, Y Zhao, M Rodriguez, Z Wu… - Cells, 2023 - mdpi.com
Over the recent decades, the use of extracellular vesicles (EVs) has attracted considerable
attention. Herein, we report the development of a novel EV-based drug delivery system for …