Activity-based protein profiling (ABPP) is a technique that uses highly selective active-site
targeted chemical probes to label and monitor the state of proteins. ABPP integrates the …

Highlights•Glycosidases carry out many essential functions across all domains of
life.•Activity-based probes can interrogate complex biological samples for glycosidase …

Emerging research supports that triclosan (TCS), an antimicrobial agent found in thousands
of consumer products, exacerbates colitis and colitis-associated colorectal tumorigenesis in …

Heparan sulfate proteoglycans (HSPGs) mediate essential interactions throughout the
extracellular matrix (ECM), providing signals that regulate cellular growth and development …

Plants contain numerous glycoconjugates that are metabolized by specific
glucosyltransferases and hydrolyzed by specific glycosidases, some also catalyzing …

Heparanase, the sole heparan sulfate (HS)-degrading endoglycosidase, regulates multiple
biological activities that enhance tumor growth, metastasis, angiogenesis, and inflammation …

Recent advances in single-particle cryo-electron microscopy (cryoEM) have resulted in
determination of an increasing number of protein structures with resolved glycans. However …

Heparanase is an endoglycosidase involved in remodeling the extracellular matrix and
thereby in regulating multiple cellular processes and biological activities. It cleaves heparan …

Activity-based protein profiling (ABPP) is an effective technology for the identification and
functional annotation of enzymes in complex biological samples. ABP designs are normally …

Heparanase has been viewed as a promising anti-cancer drug target for almost two
decades, but no anti-heparanase therapy has yet reached the clinic. This endoglycosidase …