Human vitreous in proliferative diabetic retinopathy: characterization and translational implications

IM Nawaz, S Rezzola, A Cancarini, A Russo… - Progress in retinal and …, 2019 - Elsevier
Diabetic retinopathy (DR) is one of the leading causes of visual impairment in the working-
age population. DR is a progressive eye disease caused by long-term accumulation of …

Role of leptin and adiponectin in carcinogenesis

A Bocian-Jastrzębska, A Malczewska-Herman… - Cancers, 2023 - mdpi.com
Simple Summary The involvement of leptin and adiponectin with receptors in the formation
of many types of cancer as well as their impact on the clinical course of cancer patients are …

Cardiovascular diseases and metabolic abnormalities associated with obesity: What is the role of inflammatory responses? A systematic review

N Hamjane, F Benyahya, NG Nourouti, MB Mechita… - Microvascular …, 2020 - Elsevier
Introduction Obesity is a chronic disease responsible for a high morbidity and mortality rate,
with an increasing worldwide prevalence. Obesity is associated with immune responses …

The impact of adipokines on vascular networks in adipose tissue

M Vliora, C Ravelli, E Grillo, M Corsini… - Cytokine & Growth …, 2023 - Elsevier
Adipose tissue (AT) is a highly active and plastic endocrine organ. It secretes numerous
soluble molecules known as adipokines, which act locally to AT control the remodel and …

Emerging role of adiponectin/AdipoRs signaling in choroidal neovascularization, age-related macular degeneration, and diabetic retinopathy

M Choubey, P Bora - Biomolecules, 2023 - mdpi.com
Age-related macular degeneration (AMD), a leading cause of irreversible blindness in
adults, may result in poor central vision, making it difficult to see, read, and drive. AMD is …

Biological drug therapy for ocular angiogenesis: Anti‐VEGF agents and novel strategies based on nanotechnology

ML Formica, HG Awde Alfonso… - Pharmacology Research …, 2021 - Wiley Online Library
Currently, biological drug therapy for ocular angiogenesis treatment is based on the
administration of anti‐VEGF agents via intravitreal route. The molecules approved with this …

Adiponectin inhibits high glucose‐induced angiogenesis via inhibiting autophagy in RF/6A cells

R Li, J Du, Y Yao, G Yao, X Wang - Journal of Cellular …, 2019 - Wiley Online Library
Adiponectin, one of the adipose‐derived hormone with metabolic activity, has been reported
to conversely affect angiogenesis of endothelial cells in vitro. The previous study in animal …

Adiponectin ameliorates hyperglycemia-induced retinal endothelial dysfunction, highlighting pathways, regulators, and networks

S Bushra, DW Al-Sadeq, R Bari, A Sahara… - Journal of …, 2022 - Taylor & Francis
Background The pathophysiology of diabetic retinopathy (DR) is multifaced. A low level of
circulating adiponectin (APN) in type 2 diabetes is associated with microvasculature …

Targeted blood metabolomic study on retinopathy of prematurity

Y Yang, Z Wu, S Li, M Yang, X Xiao… - … & visual science, 2020 - iovs.arvojournals.org
Purpose: This study aims at exploring alterations of major metabolites and metabolic
pathways in retinopathy of prematurity (ROP) infants and identifying biomarkers that may …

Targeting neurovascular interaction in retinal disorders

Z Fu, Y Sun, B Cakir, Y Tomita, S Huang… - International journal of …, 2020 - mdpi.com
The tightly structured neural retina has a unique vascular network comprised of three
interconnected plexuses in the inner retina (and choroid for outer retina), which provide …